SKU: 58159859833

Pacific Blue Mouse Anti-Human CD1a Antibody (S-R527)

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Description

Pacific Blue Mouse Anti-Human CD1a Antibody (S-R527)Product Specification Host Mouse Antigen CD1a Synonyms T cell surface glycoprotein CD1a; T cell surface antigen T6 Leu 6 (hTa1 thymocyte antigen); CD1A Location Cell membrane Accession P06126 Clone Number S R527 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample MOLT 4 Purification Protein G Concentration 0. 2 mg ml Conjugation Pacific Blue Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300

Product Specification


Host Mouse
Antigen CD1a
Synonyms T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6 (hTa1 thymocyte antigen); CD1A
Location Cell membrane
Accession P06126
Clone Number S-R527
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample MOLT-4
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Pacific Blue
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

CD1a is a 49-kDa type I transmembrane glycoprotein of the non-polymorphic CD1 family that folds into three extracellular Ig-like domains (α1–α3) stabilized by disulfide bonds and a short cytoplasmic tail containing the YXXZ-based tyrosine motif that drives its trafficking from the plasma membrane to late endosomes, where at pH 4.5–5.5 it loads endogenous or microbial lipid/glycolipid antigens—such as sphingolipids, mycoketides, lipopeptides or sulfatides—into its narrow hydrophobic groove; these CD1a–lipid complexes are then recycled to the cell surface for surveying by clonotypically diverse αβ and γδ T cells (including TRAV1-2− MAIT cells, NKT subsets and autoreactive TCRs) whose activation contributes to thymic selection, skin immunity, peripheral tolerance and host defense against mycobacteria, while dysregulated CD1a expression on Langerhans cells and other dendritic cells fuels inflammatory skin disorders like psoriasis, atopic dermatitis and cutaneous T-cell lymphoma, making CD1a a diagnostic marker (clone O10) and emerging therapeutic target.

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SKU: 58159859833

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