SKU: 60059061127

SHBG His Tag Protein, Human

Name: SHBG His Tag Protein, Human
Brand: 2pierres.com
SKU: 60059061127
Price: 185.00 USD
Availability: InStock
Rating: 4.7191 (28 reviews)

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Description

SHBG His Tag Protein, HumanProduct Specification Species Human Accession P04278 Amino Acid Sequence Leu30 His402, with C His tag Expression System HEK293 Molecular Weight Predicted MW: 42. 2 kDa Observed MW: 50 kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer 0. 2M PBS, pH7. 4. Reconstitution Reconstitute no more than 1 mg mL according to the size in deionized water after rapid

Product Specification

Species	Human
Accession	P04278
Amino Acid Sequence	Leu30-His402, with C-His tag
Expression System	HEK293
Molecular Weight	Predicted MW: 42.2 kDa Observed MW: 50 kDa
Purity	>95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized powder
Storage Buffer	0.2M PBS, pH7.4.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to androgens and estrogens. SHBG is found in all vertebrates apart from birds. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of SHBG. SHBG’s production is regulated under the influence of FSH on Sertoli cells, enhanced by insulin, retinol, and testosterone. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone. SHBG levels are usually about twice as high in women than in men. In women, SHBG serves to limit exposure to both androgens and estrogens. Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively. During pregnancy, due to activation of SHBG production in the liver by high estrogen levels, SHBG levels increase by five-fold to ten-fold.

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