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Description
Invivo anti-Rat TCR α/β Recombinant mAbProduct Specification Host Mouse Antigen TCR Location Cell membrane Accession A0A8I6ABG9 Clone Number S 3806 Antibody Type Mouse mAb Application FCM, in vivo T cell depletion Reactivity Rt Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 2 to 8 C for 2 weeks under sterile
Product Specification
| Host | Mouse |
| Antigen | TCR α/β |
| Location | Cell membrane |
| Accession | A0A8I6ABG9 |
| Clone Number | S-3806 |
| Antibody Type | Mouse mAb |
| Application | FCM, in vivo α/β T cell depletion |
| Reactivity | Rt |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
TCR α/β protein, the defining heterodimer of the αβ T-cell lineage, is a disulfide-linked transmembrane receptor whose extracellular amino-terminal variable (Vα/Vβ) and constant (Cα/Cβ) Ig-like domains collectively form an antigen-binding groove that recognizes a composite ligand consisting of a peptide non-covalently nestled within the groove of an MHC molecule; this interaction is stabilized by two paired immunoglobulin superfamily domains and anchored to the T-cell membrane via stalk, transmembrane and short cytoplasmic regions that associate with CD3 γε, δε and ζζ signaling subunits, so that ligand-induced conformational change in the αβ heterodimer triggers phosphorylation of ITAMs and initiates the calcium- and kinase-dependent cascade leading to T-cell activation, proliferation and differentiation, thereby making the TCR α/β protein the central sensor that converts extracellular peptide-MHC information into intracellular immune decisions.
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