SKU: 62382861793

IL-23 Protein, Human

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Description

IL-23 Protein, HumanProduct Specification Species Human Synonyms SGRF, IL 23p19, CLMF p40, IL 12 subunit p40, NKSF2 Accession Q9NPF7P29460 Amino Acid Sequence p19: Arg20 Pro189, with N terminal His Tag p40: Ile23 Ser328 Expression System CHO Molecular Weight p19: 18 22 kDa (Reducing) p40: 38 42 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4

Product Specification


Species Human
Synonyms SGRF, IL-23p19, CLMF p40, IL-12 subunit p40, NKSF2
Accession Q9NPF7、P29460
Amino Acid Sequence

p19: Arg20-Pro189, with N-terminal His Tag
p40: Ile23-Ser328
Expression System CHO
Molecular Weight

p19: 18-22 kDa (Reducing) p40: 38-42 kDa (Reducing)
Purity >95% by SDS-PAGE and HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Nature. 2010 Apr 29;464(7293):1371-5.
Nat Med. 2015 Jul;21(7):719-29.

Background

Interleukin-23 (IL-23) is a heterodimeric pro-inflammatory cytokine belonging to the IL-12 family, primarily secreted by dendritic cells and macrophages. Composed of a unique p19 subunit and a shared p40 subunit with IL-12, IL-23 functions through a receptor complex consisting of IL-12Rβ1 and the IL-23-specific receptor subunit IL-23R.
IL-23 is recognized as a key upstream regulator in multiple autoimmune diseases, including psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and multiple sclerosis (MS). Genome-wide association studies have identified IL-23R gene variants linked to susceptibility for psoriasis, IBD, and Behçet's disease. In the gut, IL-23 exhibits a selective inflammatory profile, controlling local IL-17 production while sparing systemic immunity, making it an attractive therapeutic target that preserves host defense mechanisms.

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SKU: 62382861793

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4.4 ★★★★★
Based on 13 reviews
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Product Reviews
A
Verified Purchase
Andrew Platek
Lexington, US
★★★★★ 5
Thought Provoking
Format: Kindle
I bought this book after I heard the author on a podcast. Growing up in the US we have been inundated with the story that the collapse of the Soviet Union was an inevitable triumph of liberal, Western values. I had my doubts. Even poorly run dictatorships can muddle along for years. What the author did was center Gorbachev in the story. He was the eye of the storm. It was the terrible combination of Gorbachev’s ambitious idealism and gross ineptitude that led to the dismantling of the Soviet Union. Unlike much of Marxist historical narratives which emphasize the forces of history; the author shows that it’s individuals who shape events and are shaped by them. A different person than Gorbachev could have turned the tide in a different direction and left us a different world than we have today. This is a history book that teaches lessons not just about the Soviet Union but about human history in general.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 1, 2025
L
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Luca turin
Houston, US
★★★★★ 5
A compelling account of the fall of the USSR
Format: Kindle
Zubok describes blow by blow the series of decisions that sent the USSR towards disaster. Gorbachev, widely hated in Russia, comes across as principled but indecisive, ignorant of economics, and incapable of translating his worship of Lenin into coherent action. The book reads like a thriller despite the density of facts. Zubok is a pessimist, but his thesis is convincing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 21, 2024
M
Verified Purchase
Miguel
Boise, US
★★★★★ 5
Fascinating, an against the grain account of the perestroika era
Format: Kindle
Gorbachev is hailed as a hero in the West but the book tells the story of a meek, naive individual that precipitated the fall of the Soviet Union creating suffering and an a!most unprecedented calamity.
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Reviewed in the United States on December 19, 2025
K
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Khatuna Brady
Charlottesville, US
★★★★★ 2
A masterfully falsified history of the late Soviet developments
Format: Paperback
This book represents academic propaganda, providing some interesting insights into important events. Some details are true, but some crucial details are omitted. It represents a sanitized version of Russia's modern history. It provides misleading information about Gorbachev's constitutional reforms, aimed at partitioning of 15 republics into 53 confederation entities. Originally, the targeted republics were Kazakhstan, Moldova, Georgia, Azerbaijan, Ukraine, etc. Those conflicts were manufactured by the Soviet center to discredit "nationalists," facilitate the partition of national republics, and grant Moscow right to protect ethnic minorities. According to Starovoitova, Bakatin, Yakovlev, and a few other primary sources, the Soviet security services led special operations in the Caucasus and Central Asia to provoke those conflicts. Zubok avoids citing those parts. Using the imperial approach of "divide and rule," Moscow attempted to become a peacekeeper in the conflicts it created between different ethnicity. In addition to fragmenting the republics with well-developed national identities, Gorbachev's new constitution would revoke their right to leave the USSR, written in Lenin's 1922 Constitution (Shakhnazarov, 1992). Zubok does not explain any of it. His book is an effort to protect the truth and conceal facts with Russian myths and lies about nationalism (also referred to as Nazism). Notably, Zubok does not recognize non-Russian republics and describes them as "territories." He mentions Pitsunda as a resort on the Black Sea, not as Georgia. For lying about the genocidal ethnic cleansing conducted by the Russian military against the Georgian population of Abkhazia, Zubok owes apology to the victims of conflicts and wars initiated by Gorbachev and carried on by Yeltsin. The story about "the hardliners coup against Gorbachev" is also a big fat lie. American scholars, Amy Knight, John Dunlop, and William Odom provide more accurate insights. For Russian sources, read Marshal Shaposhnikov or Aleksandr Lebed's memoirs (1995) and listen to Gennady Yanaev's interview (2009). According to Mitrokhin archives (original), the August 1991 coup was an active measure the KGB developed per Gorbachev's request. The so-called coup was part of Gorbachev's constitutional reform, which would lead to the removal of unfriendly leaders (including Yeltsin) from the republics. It failed because the Soviet military brass, foremost Pavel Grachev, had defected to Yeltsin earlier in 1991. When you read a book by a seasoned Russian propagandist, like Zubok or Trenin, take it with a grain of salt, because it will always contain a mix of lies and truth.
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Reviewed in the United States on March 16, 2023
U
Verified Purchase
Ujjval K. Vyas
Cuba, US
★★★★★ 5
An important work and worth the time.
Format: Hardcover
Real scholarship addressing difficult but important topics in history, economic history, and development. What every economist should read to think much more deeply about how institutions, culture, and human agency interact. At the same time, scholars like the three co-authors demonstrate that there still remains the possibility of doing work that isn’t larded with ideological or activist posturing. Highly recommended.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026

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