SKU: 63742686173

Desmoglein 3 Recombinant Rabbit mAb (SDT-3213-33)

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Description

Desmoglein 3 Recombinant Rabbit mAb (SDT-3213-33)Product Specification Host Rabbit Antigen Desmoglein 3 Synonyms Desmoglein 3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P32926 Clone Number SDT 3213 33 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A431, HaCaT Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen Desmoglein 3
Synonyms Desmoglein-3; 130 kDa pemphigus vulgaris antigen (PVA); Cadherin family member 6; CDHF6; DSG3
Immunogen Synthetic Peptide
Location Cytoplasm, Cell membrane
Accession P32926
Clone Number SDT-3213-33
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample A431, HaCaT
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:500 Hu

Background

Desmoglein-3 (Dsg3) is a calcium-dependent transmembrane glycoprotein and a key component of desmosomes, specialized cell-cell adhesion structures primarily found in stratified squamous epithelia such as the skin and oral mucosa; it functions to maintain tissue integrity by anchoring intermediate filaments of the cytoskeleton to sites of intercellular contact, and beyond its structural role, Dsg3 actively regulates epithelial homeostasis by suppressing p53-mediated stress responses, thereby acting as an anti-stress protein that protects keratinocytes from apoptosis induced by UVB, mechanical stress, or genotoxic agents, while also promoting cancer cell migration and invasion through activation of the AP-1 transcription factor and PKC-dependent phosphorylation of ezrin, and its autoimmune targeting by autoantibodies results in the loss of adhesion and blister formation characteristic of pemphigus vulgaris, making Dsg3 a central player in both physiological epithelial cohesion and pathological processes including cancer metastasis and autoimmune blistering diseases.

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SKU: 63742686173

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4.2 ★★★★★
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Matthew M
Fort Morgan, US
★★★★★ 5
Worth the price
Scent: Face Wash, Size: 5.1 Fl Oz (Pack of 1)
Although I was hesitant to buy this at first since it’s about twice the price as the facial cleansers I normally use, it’s by far the best face wash I’ve ever used. It exfoliates the skin very well and leaves your face feeling clean after use. Definitely worth the extra few dollars
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Reviewed in the United States on July 23, 2024
R
Verified Purchase
Rico A
Boise, US
★★★★★ 5
For all skin type
Scent: Face Wash, Size: 5.1 Fl Oz (Pack of 2)
It gives the face a very clean wash compare to others i have use in the past, best i have seen so far.
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Reviewed in the United States on October 25, 2025
R
Verified Purchase
Reviews by ILoveAmazon15
Birmingham, US
★★★★★ 3
Greasy, does not blend in well but does not leave white marms
Overall, when researching this product, I saw that it does not leave the white residue on your face like normal sunscreen does, I’m looking for a face moisturizer first with SPF but this one feels more just like an SPF sunscreen. It is pretty greasy shortly and after a few hours of having it on, especially when sweating it makes my face feel really oily, and also it does not blend in very well such as pretty much like I just mentioned you could still feel it on your face a couple hours later but if the no white resident is the most important thing for you, it does not leave that residue. It’s cruelty free and vegan product (no animal products in it or animal testing done) so that’s good but I will most likely not be purchasing this .
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Reviewed in the United States on June 24, 2024
A
Verified Purchase
Alexandra Held
Houston, US
★★★★★ 5
So so good!!!
Scent: Face Wash, Size: 5.1 Fl Oz (Pack of 1)
This face wash is a game changer! From texture to smell it is perfect. I ordered this for my husband to replace his usual "routine" of washing his face in the shower with bar soap (gasp!). I not-so-sneakily put this in the shower and at his first sample of it he was hooked. It's the only face wash he's tried and actually likes to use on a daily basis. Also, the price point is great! Definitely recommend for anyone seeking an awesome face wash at a perfect price.
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Reviewed in the United States on November 12, 2020
K
Verified Purchase
Katherine Philbrick
Massapequa, US
★★★★★ 5
A lot of these poems leave me feeling like an idiot
Format: Paperback
This is the type of book I read at 3 am when I can't sleep. Stevens' poetry just makes me feel so calm, even though the content in his poetry is not in fact anywhere near the realms of calm. Overall, I would say, the content is hard-hitting. I'm not going to pretend I understand all of his ideas and everything he says- I definitely don't. A lot of these poems leave me feeling like an idiot. But when I am able to figure something out, it all starts to click and I am left with a lump in my throat. Although I don't necessarily understand everything when it comes to this collection, I think that it is a good thing. It just shows the high level of his talent manages to knock me off my feet. Well, anyway, I got my first peak of this collection at uni. I was so intrigued by it that I bought it during winter break. While reading it I found out one of my professors is an editor of the edition that I bought. Rad. But also, the thing is, (and I have thought this many times before,) uni can only teach you so many things. I learned much more about Stevens' poetry by reading it myself than what I learned from uni. Like, without reading basically this whole collection, I would have never learned that Stevens is, for the most part, a Romantic. He's a lot like Wordsworth, I think. He inherits so many of the Romantic feelings, ideas and philosophies but he still manages to stay modern at the same time. I am obsessed with the Romantic poets so in my mind, that's what makes him stand out. I love the fact that he manages to tie modernism and Romanticism together, it is a real treat for me to read. Even though it's not really talked about, I would say my favorite poem of his is "Another Weeping Woman". It is so quick and beautiful and earnest and a good poem to read when you lose one of your loved ones. Over the past couple of years I have really warmed up to poetry. I'm not a huge American lit person in general but I always tell people that Stevens is one of my favorites, if not my favorite American poet. Everything about his work seems so personal, like when you're reading it, it feels like he is speaking directly to you. It feels so natural but honestly nothing about reading his poetry is easy. It is tough to figure out. But I enjoyed taking the time to sit down and try to hypothesize all that is going on in his works. He is dark, so dark and yet manages to feel so light, so beautiful. He delivers the best of both worlds in my eyes and that's why I will revisit this collection again and again and again. It never stops being so hideous and so beautiful at the same time.
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Reviewed in the United States on January 11, 2017

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