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Description
PSAT1 Recombinant Rabbit mAb (S-3054-5)Product Specification Host Rabbit Antigen PSAT1 Synonyms Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase (PSAT); PSA Immunogen Recombinant Protein Location Cytoplasm Accession Q9Y617 Clone Number S 3054 5 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample HEK 293, HepG2, HeLa, K562 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | PSAT1 |
| Synonyms | Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase (PSAT); PSA |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | Q9Y617 |
| Clone Number | S-3054-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | HEK-293, HepG2, HeLa, K562 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:100 | Hu |
Background
PSAT1 (phosphoserine aminotransferase 1) is a pyridoxal-5′-phosphate-dependent enzyme that catalyzes the reversible conversion of 3-phosphohydroxypyruvate and glutamate into 3-phosphoserine and α-ketoglutarate, representing the second step in the de novo L-serine biosynthesis pathway that fuels one-carbon metabolism, nucleotide and phospholipid production, and cellular redox balance; highly expressed in liver, brain and proliferating tissues, PSAT1 is frequently up-regulated in multiple cancers where its increased activity supports tumor growth, metastasis and chemoresistance by maintaining serine/glycine homeostasis and NADPH generation through mitochondrial and cytosolic isoforms, while inherited mutations in PSAT1 cause Neu-Laxova syndrome, a severe congenital disorder characterized by microcephaly, ichthyosis and lethality, underscoring its essential role in both normal development and disease.
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