SKU: 66835925679

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 66835925679

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john jeffrey elliott
Lake Worth, US
★★★★★ 1
TOO SMALL
Size: Medium, Color: Blue
Nice socks, but they are way too small. Says they fit size 6 - 10. I kept 3 ( I wear size 8) and gave 3 to my daughter (size 8.5). We both agreed that they were just too small.
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Reviewed in the United States on May 12, 2026
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Mar Gee
Omaha, US
★★★★★ 5
Style and comfort
Size: Medium, Color: Black
Exactly what I was looking for. Style and sock thickness and comfort.
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Reviewed in the United States on December 14, 2025
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Amazon Customer
Dallas, US
★★★★★ 5
Comfortable
Size: Medium, Color: Blue
So comfortable! They stay up perfectly love love love
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Reviewed in the United States on December 7, 2025
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Excelente
New York, US
★★★★★ 5
Excelente calidad
Color: Black, Size: Standard - 4 Panel
Excelente
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Reviewed in the United States on June 1, 2026
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DCP
Phoenix, US
★★★★★ 5
Great value, perfect for our infant room!
Color: Black, Size: Standard - 4 Panel
Great product, sturdy design and easy to build! It is a fairly light weight item, which aids in the maneuverability of the divider. The color was as described and is dark enough to block the light from our sleeping infants! I do love that you are able to see through the slats and see the child sleeping- if you are looking for something with MORE privacy, this is not it. It has great coverage area and is dark and a wonderful value for the price, however, you are able to see through the areas where each panel connects!
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Reviewed in the United States on August 18, 2025

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