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Description
ATF1 Recombinant Rabbit mAb (S-2883-124)Product Specification Host Rabbit Antigen ATF1 Synonyms Cyclic AMP dependent transcription factor ATF 1; cAMP dependent transcription factor ATF 1; Activating transcription factor 1; TCR ATF1; Atf1 Immunogen Synthetic Peptide Location Nucleus Accession P81269 Clone Number S 2883 124 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample HeLa, 293T, A431, K562, RAW264. 7 Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | ATF1 |
| Synonyms | Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; TCR-ATF1; Atf1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P81269 |
| Clone Number | S-2883-124 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, 293T, A431, K562, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu, Ms |
Background
ATF1 (activating transcription factor 1) is a 271-amino-acid basic leucine-zipper (bZIP) protein that forms homo- or heterodimers with c-Jun, CREB or other bZIP partners to bind the consensus cAMP response element 5′-TGACGTCA-3′, thereby functioning as a stimulus-inducible transcriptional activator in cAMP, MAPK, calcium and stress-signaling cascades that govern proliferation, survival, melanocyte differentiation, synaptic plasticity and memory; it is subject to phosphorylation-driven control (notably by PKA at Ser63 and by p38/MSK1 at Ser63/121), acetylation and ubiquitination, is frequently fused to either EWSR1 or FUS in Ewing sarcoma and angiomatoid fibrous histiocytoma through t(12;22) or t(12;16) chromosomal translocations that convert it into an aberrant transcriptional activator, and its locus at 12q13 is co-amplified with CDK4 in a variety of sarcomas, underscoring its dual role as both a tightly regulated physiological transcription factor and an oncogenic driver.
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