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Description
APC Mouse Anti-Human CD59 Antibody (S-R567)Product Specification Host Mouse Antigen CD59 Synonyms CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF 20; HRF20); MAC inhibitory protein (MAC IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 Location Secreted, Cell membrane Accession P13987 Clone Number S R567 Antibody Type Mouse mAb Isotype IgG2a Application FCM
Product Specification
| Host | Mouse |
| Antigen | CD59 |
| Synonyms | CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor (HRF-20; HRF20); MAC-inhibitory protein (MAC-IP); MEM43 antigen; Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis (MIRL); Protectin; MIC11; MIN1; MIN2; MIN3; MSK21 |
| Location | Secreted, Cell membrane |
| Accession | P13987 |
| Clone Number | S-R567 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood cells |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD59, also known as membrane inhibitor of reactive lysis (MIRL) or protectin, is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a crucial role in regulating the complement system, an essential part of the innate immune response. It is widely expressed on various human cells and tissues, including erythrocytes, leukocytes, fibroblasts, and epithelial cells. The primary function of CD59 is to inhibit the formation of the membrane attack complex (MAC), thereby preventing complement-mediated cell lysis. This protective mechanism is vital for maintaining cell integrity and preventing excessive immune-mediated damage.
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4.3 ★★★★★
Based on 25 reviews
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Product Reviews
★★★★★ 5
Excellent product at a very good price. I will buy it again.
This is an excellent product at a fair price. The cream creates a barrier that protects the skin, while mosturizes it. leaves hands very soft, and it doesn't feel greasy. I know that this is a favorite brand (Avene) in France, and Amazon offers it at a very good price. I will buy it again, from Amazon. I bought it this year in Paris, and it was more expensive there.
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Reviewed in the United States on May 27, 2015
★★★★★ 1
Drying formula and smell bad
Smell so bad and made my hands dry instead of moisturizing. The formula is watery. Maybe it’s fake or expired I am not sure.
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Reviewed in the United States on December 25, 2025
★★★★★ 5
Obsessed. Soothing, effective, fragrance-free, incredibly healing
Style: Tolerance Daily Foaming Facial Cleanser
I’ve been loving this so much I bought a second bottle after a few days of using it. It has all the skin soothing benefits of the tolerance lotion cleanser, but it’s also a really great cleanser. It’s almost not noticeable how good it is at cleansing because your skin doesn’t feel stripped after, but it takes things off really quickly. I was worried because it doesn’t foam a lot and it feels so nurturing — much like the tolerance lotion cleanser (which I use as a second cleanse when my skin needs a few days to recover from something like a derm office treatment) — but when I wash again with my favorite HG cleanser nothing extra comes off, and I tested it twice on waterproof eyeliner that I’d swiped on my forearm for an hour or so, the eyeliner dissolved and wiped off with two or three gentle swipes. It has a very emollient texture, so when you rub it against your skin it slips so easily you don’t realize it’s dissolving and taking things away because there is no friction. So it’s great at taking off makeup, it’s AMAZING at cleaning makeup brushes, and IT DOES NOT BURN MY EYES AT ALL. Also, it is FRAGRANCE-FREE… before I bought it I read a review complaining about smelling a citrus fragrance, that person either has some sort of brain tumor or something spilled on their bottle when it was in a warehouse because this is definitely a fragrance-free product.
Prior to trying this, I had tried another cleanser that gave me weird acne hives all over my chest (never happened to me before) and I was struggling to heal the acne and the irritation. I noticed an immediate difference when I started using the tolerance cleanser on it; the fresh redness went away, the acne started healing, and the post-inflammatory hyperpigmentation has been healing fast. So I’ve been using this on my body as well and it’s soothing and moisturizing in all the places where other things have been drying. I have mild rosacea and I hadn’t realized how irritated my skin was from the last thing I’d tried until after 5 days or so of using this my skin tone looked much more even and the stubborn PIH I have from a two-zit hormonal breakout a month ago finally looked dramatically lighter (as recently as the week before, I’d needed to cover them with high-coverage concealer).
Because this doesn’t foam much, some people might not realize how well it’s cleaning… I encourage you to judge it based on how your skin looks and feels. Since it is very emollient though, I do think it’s important to use it with a face wash scrubber or washcloth just to ensure you’re getting some mild mechanical exfoliation and clearing away skin cells that could be trapping stuff in your pores. For this reason, I do wash my face with this twice so the first wash can get off makeup/debris/oil and then the second wash can really penetrate and clean my skin.
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Reviewed in the United States on February 15, 2026
★★★★★ 5
No Scent and Gentle
Style: Tolerance Daily Foaming Facial Cleanser
I broke out in a case of Perioral Dermatitis recently and bought this product to help before I could see my doctor. Avene Tolerance facial cleanser has no scent and is very gentle on my skin. It didn’t burn when washing with this product, and even helped to slough off the dead skin around my lips. My face feels clean, not dry. I am still going to see my doc to get an RX for the inflammation, but I do believe this product helped to alleviate the dryness and tightness of my skin and lips. I’ve used other Avene products and I’m very happy with them. Even though these products are more expensive, to me they are well worth the money because they are much more gentle on the skin than any other products I’ve used. I will buy this product again just because of the fact that it’s so gentle. PS: at the time of purchase for this product, I also bought Avene’s Tolerance Control Skin Recovery Cream (you don’t need to use a lot of this one on your entire face), and Avene’s Cicalfate for lips. Between these 3 products, my lips and skin feel a lot better (however, I will still see my doctor because I have Crohn’s Disease and Perioral Dermatitis is considered an extra-intestinal side effect of Crohn’s).
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Reviewed in the United States on March 20, 2026
★★★★★ 5
Gentle everyday cleanser!
Style: Tolerance Daily Foaming Facial Cleanser
My go to nightly cleanser! Gentle yet effective. Removes makeup without leaving any residue behind. Also does not dry out my skin or cause breakouts! I would say it’s more of a cream cleanser though. It does not really foam up. It’s a decent size bottle for the price. The pump dispenser is an added plus!
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Reviewed in the United States on May 19, 2026