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Description
S6 Ribosomal Protein Recombinant Rabbit mAb (S-479-1)Product Specification Host Rabbit Antigen S6 Ribosomal Protein Synonyms Small ribosomal subunit protein eS6, 40S ribosomal protein S6, Phosphoprotein NP33, RPS6 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P62753 Clone Number S 479 1 Antibody Type Recombinant mAb Application WB, IHC P, IP, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Av, Bv, Rb, Xe, Fs Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | S6 Ribosomal Protein |
| Synonyms | Small ribosomal subunit protein eS6, 40S ribosomal protein S6, Phosphoprotein NP33, RPS6 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P62753 |
| Clone Number | S-479-1 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Av, Bv, Rb, Xe, Fs |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC | 1:500 | |
| ICFCM | 1:5000 |
Background
Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis. tudies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate eS6 and that S6K1 and S6K2 predominate this function. Pathways leading to the induction of human eS6 phosphorylation have been found to enhance IL-8 protein synthesis. This mechanism is dependent on A/U-rich proximal sequences (APS) found in the 3'UTR of IL-8 immediately after the stop codon.
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