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Description
BAFFR Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BAFF R; BAFFR; BR3; CD268; TNFRSF13C Accession Q96RJ3 Amino Acid Sequence Ser7 Ala71 with Human IgG1 Fc at C Terminus Expression System HEK293 Molecular Weight 35 50kDa (Reducing) Purity > 95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml
Product Specification
| Species | Human |
| Synonyms | BAFF R; BAFFR; BR3; CD268; TNFRSF13C |
| Accession | Q96RJ3 |
| Amino Acid Sequence | Ser7-Ala71 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 35-50kDa (Reducing) |
| Purity | > 95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Rolink, A.G. and F. Melcher (2002) Curr. Opin. Immunol. 14:266. |
Background
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C), also known as B-cell-activating factor receptor (BAFFR) or CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFFR promotes B cell survival and is crucial for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B), and BAFF receptor (BAFFR/BR3/TNFRSF13C). These receptors are type III transmembrane proteins without a signal peptide. BAFFR is highly expressed in the spleen, lymph nodes, and resting B cells, and at lower levels in activated B cells, resting CD4+ T cells, the thymus, and peripheral blood leukocytes. BAFF knockout mice lack mature B cells, as do A/WySnJ mice with defects in BAFF-R intracellular signaling, indicating that BAFFR is the critical receptor for BAFF during B lymphopoiesis. It is hypothesized that elevated levels of BAFFR/TNFRSF13C (CD268) may contribute to autoimmune disease pathogenesis by enhancing the survival of autoreactive B cells.
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