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Description
VSIG4 Recombinant Rabbit mAb (SDT-2737-61)Product Specification Host Rabbit Antigen VSIG4 Synonyms V set and immunoglobulin domain containing protein 4; Protein Z39Ig; CRIg; Z39IG Immunogen Recombinant Protein Location Membrane Accession Q9Y279 Clone Number SDT 2737 61 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample THP 1 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | VSIG4 |
| Synonyms | V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; CRIg; Z39IG |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | Q9Y279 |
| Clone Number | SDT-2737-61 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | THP-1 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
VSIG4 (V-set and immunoglobulin domain-containing 4), also known as CRIg, is a transmembrane glycoprotein of the B7-related family that is selectively expressed on resting tissue macrophages; it functions both as a potent negative regulator of T-cell activation and IL-2 production and as a complement receptor that binds C3b/iC3b-opsonized particles, thereby mediating rapid phagocytic clearance of pathogens while inhibiting the alternative complement pathway convertase to limit inflammation and maintain peripheral immune tolerance.
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Exchange/Return Notes
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