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Description
TrkC Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TrkC, Ntrk3 Accession Q96CY4 Amino Acid Sequence Cys32 Asp428, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TrkC, Ntrk3 |
| Accession | Q96CY4 |
| Amino Acid Sequence | Cys32-Asp428, with C-terminal Human IgG1 Fc CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Khotskaya Y B. et al. (2017). Targeting TRK family proteins in cancer. Review. 173:58-66. |
Background
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of neurotrophins to TRK proteins induces receptor dimerization, phosphorylation, and activation of the downstream signaling cascades via PI3K, RAS/MAPK/ERK, and PLC-gamma. TrkC functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. TrkC is a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
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4.1 ★★★★★
Based on 11 reviews
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Product Reviews
★★★★★ 5
Soft, Warm, lightweight, Cozy
Color: Cream, Size: Full/Queen
When I first received this blanket I washed it by itself in cold water with detergent. I did not use a fabric softener or a fabric sheet. I air dried it completely and then put it in my dryer on air fluff for 10 minutes. No shedding and it came out just like I received it. I was concerned about shedding with some of the reviews but I had no issues with that whatsoever. It's warm yet lightweight. I didn't want anything that would make me overly hot because I'm always hot anyway. It takes that cool edge off when you still want your overhead fan on. My daughter said she likes it better than the one she has. I can't remember the brand. I feel it has a good quality. Just make note to wash it as instructed and it'll hold up well and look just as nice as the way you bought it. I'm not sure how the other reviewers that didn't leave 5 stars washed there's, but it couldn't have been the correct way.
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Reviewed in the United States on September 20, 2025
★★★★★ 5
Soft, warm, sometimes shed
Color: Shadow Grey, Size: Full/Queen
LOVE these blankets! The only downside is some of them shed. They will keep you so warm and they are very soft.
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Reviewed in the United States on April 14, 2026
★★★★★ 5
Thick, fluffy, very warm
Color: Chino, Size: Throw/Throw XL
Very nice... but was looking for something more lightweight.
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Reviewed in the United States on May 28, 2026
★★★★★ 5
Pretty, Soft and Warm Blanket Brightens Bed And Great Value
Pretty blanket
Color as shown, matches other linens !
Washes easily, still soft after much use, Excellent price for this brand
Fluffy even after many trips in the washer and dryer
Very good quality ,covers bed, kept us warm on cold nights
Kept kids bundled up and cozy on car trips
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Reviewed in the United States on January 16, 2026
★★★★★ 4
Great size and warm but didn't feel as luxurious and soft or thick as I thought
Color: Shadow Grey, Size: Twin/Twin XL
This blanket is not quite at fluffy or thick as I would have wanted. It feels thin but soft. It does keep me warm though and it's the perfect size to have multiple people cuddle on the couch while watching a movie?
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Reviewed in the United States on February 22, 2026
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