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Description
TBP Recombinant Rabbit mAb (S-886-57)Product Specification Host Rabbit Synonyms TATA box binding protein, TATA sequence binding protein, TATA binding factor, TATA box factor, Transcription initiation factor TFIID TBP subunit, GTF2D1, TF2D, TFIID Immunogen Synthetic Peptide Location Nucleus Accession P20226 Clone Number S 886 57 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ICFCM, IP Reactivity Hu, Rt Predicted Reactivity Mq, Bv, Hm, Ms, Av Purification Protein A
Product Specification
| Host | Rabbit |
| Synonyms | TATA-box-binding protein, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit, GTF2D1, TF2D, TFIID |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P20226 |
| Clone Number | S-886-57 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu, Rt |
| Predicted Reactivity | Mq, Bv, Hm, Ms, Av |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| ICC | 1:100 | |
| ICFCM | 1:500 |
Background
The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP is a subunit of the eukaryotic general transcription factor TFIID. TFIID is the first protein to bind to DNA during the formation of the transcription preinitiation complex of RNA polymerase II (RNA Pol II). As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. TBP is also involved in DNA melting (double strand separation) by bending the DNA by 80° (the AT-rich sequence to which it binds facilitates easy melting). The TBP is an unusual protein in that it binds the minor groove using a β sheet.
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