SKU: 69421425830

FGF-6 Protein, Human

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Description

FGF-6 Protein, HumanProduct Specification Species Human Synonyms Fibroblast growth factor 6, FGF 6, Heparin secretory transforming protein 2 (HST 2; HSTF 2), Heparin binding growth factor 6 (HBGF 6) Accession P10767 Amino Acid Sequence Gly41 Ile208 Expression System E. coli Molecular Weight 14 15 kDa (Reducing) Purity >95% by SDS PAGE, >90% by HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4

Product Specification


Species Human
Synonyms Fibroblast growth factor 6, FGF-6, Heparin secretory-transforming protein 2 (HST-2; HSTF-2), Heparin-binding growth factor 6 (HBGF-6)
Accession P10767
Amino Acid Sequence

Gly41-Ile208
Expression System E.coli
Molecular Weight

14-15 kDa (Reducing)
Purity >95% by SDS-PAGE, >90% by HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Reference

Genes & Dev. 1997;11(16):2040-2051.
Nat Commun. 2020;11(1):1421.

Background

Fibroblast growth factor 6 (FGF-6), also designated as HST2 or HBGF-6, is a secreted peptide growth factor belonging to the paracrine FGF subfamily. The FGF6 gene, located on human chromosome 12p13, encodes an 18.9 kDa protein that exhibits the highest expression in skeletal muscle and myogenic progenitor cells throughout embryonic development and adulthood. FGF-6 binds preferentially to fibroblast growth factor receptor 4 (FGFR4) with heparan sulfate proteoglycan co-receptor dependency, triggering downstream signaling through the MAPK/ERK1/2 and PI3K/AKT pathways.Functionally, FGF-6 operates as a dose-dependent regulator of myogenesis, promoting satellite cell proliferation at high concentrations and initiating myogenic differentiation via calcineurin-dependent pathways at lower concentrations. Beyond muscle physiology, FGF-6 exhibits pleiotropic functions in bone remodeling, iron homeostasis, thermogenesis, and oncogenesis, harboring both regenerative and tumorigenic activities.
Shipping Notes
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Exchange/Return Notes
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SKU: 69421425830

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4.1 ★★★★★
Based on 25 reviews
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Product Reviews
S
Verified Purchase
Staci M. L.
Belleville, US
★★★★★ 5
Great for SuperChewers. Keeps my Golden busy.
Color: Bear, Color: Bear
My dog loves it and it keeps her busy for a while. She actually pulls it out of her toy basket and brings it to me when she wants it filled. I break her treats into some pieces that are easy to get and some a little harder. This way she doesn’t get them too fast or loose interest if they’re harder to get. Also, she’s had it for 3 months and there’s barely a mark on it and she’s still a puppy that chews her toys to pieces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
J
Verified Purchase
Jen M.
Carnegie, US
★★★★★ 5
Durable, cute, & smells so good!
Color: Bear
OMG- didn’t expect this to be my dog’s favorite stuffable dog chew, but it is!! This durable rubber like dog chew is still intact and smells like blueberries after over 2 months! Great for hours with each new treat! Am buying another, when I need to :) great value
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 4, 2026
D
Verified Purchase
DZ
Carnegie, US
★★★★★ 4
Mostly happy
Color: Grape
Have a 1 1/2 yr old Belgian Malinois who needs things to do. I bought these and he loved it. Bad thing, it took him 1 day to chew the rope off both grape and pineapple. The stems on the cherry were also chewed off. The rest of the toy is intact and he still loves it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 14, 2026
M
Verified Purchase
Marcie Greer
Bozeman, US
★★★★★ 5
Very durable!
Color: Cherries
Pups love it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 30, 2026
M
Verified Purchase
Mrs. H.
Louisville, US
★★★★★ 3
Came apart.
Color: Cherries
We were playing with it and the green part pulled off of the red part. I'm pretty sure that is not supposed to happen. I took the green part away from the dog because that part is too small for my pup to play with. But we continue to play with the red part. My dog likes the texture and the bounciness.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 26, 2026

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