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Description
OPA1 Recombinant Rabbit mAb (S-2189-65)Product Specification Host Rabbit Antigen OPA1 Synonyms Dynamin like GTPase OPA1, mitochondrial; Optic atrophy protein 1; KIAA0567 Immunogen Synthetic Peptide Accession O60313 Clone Number S 2189 65 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample MCF7, A431, LNCaP, PANC 1, mouse brain, PC 12, rat brain Predicted Reactivity Or Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | OPA1 |
| Synonyms | Dynamin-like GTPase OPA1, mitochondrial; Optic atrophy protein 1; KIAA0567 |
| Immunogen | Synthetic Peptide |
| Accession | O60313 |
| Clone Number | S-2189-65 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | MCF7, A431, LNCaP, PANC-1, mouse brain, PC-12, rat brain |
| Predicted Reactivity | Or |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
The OPA1 protein, encoded by the OPA1 gene, is a dynamin-related GTPase located in the inner mitochondrial membrane, playing a crucial role in mitochondrial fusion, cristae structure maintenance, and oxidative phosphorylation. It exists in two forms: the long isoform (L-OPA1) that promotes mitochondrial fusion and the short isoform (S-OPA1) generated by proteolytic cleavage, which has recently been shown to maintain mitochondrial energetics and cristae structure under stress conditions. Mutations in the OPA1 gene are associated with optic atrophy type 1, a condition characterized by progressive vision loss due to optic nerve degeneration.
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