SKU: 70681136643

Biotin Mouse Anti-Human CD42a Antibody (S-4391)

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Description

Biotin Mouse Anti-Human CD42a Antibody (S-4391)Product Specification Host Mouse Antigen CD42a Synonyms Platelet glycoprotein IX; GP IX; GPIX; Glycoprotein 9; GP9 Location Membrane Accession P14770 Clone Number S 4391 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Fresh human peripheral blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Mouse
Antigen CD42a
Synonyms Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9; GP9
Location Membrane
Accession P14770
Clone Number S-4391
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Fresh human peripheral blood cells
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD42a, also known as glycoprotein IX (GPIX), is an essential subunit of the platelet surface glycoprotein Ib-IX-V complex. This complex serves as the primary receptor for von Willebrand factor (vWF) and plays a central role in platelet adhesion, thrombus formation, and primary hemostasis. CD42a non-covalently associates with other subunits such as glycoprotein Ibα (GPIbα) and glycoprotein Ibβ (GPIbβ) to maintain the structural stability and proper membrane expression of the receptor complex. Upon vascular injury, the CD42a-containing complex rapidly binds exposed vWF, mediating firm platelet adhesion to the subendothelial matrix under high shear stress and initiating downstream signaling that leads to platelet activation and aggregation. Mutations in the CD42a gene (GP9) cause the rare autosomal recessive disorder Bernard-Soulier syndrome, characterized by giant platelets, thrombocytopenia, and a severe bleeding tendency. Furthermore, as a platelet-specific marker, CD42a holds significant value in flow cytometry, quality assessment of platelet transfusion, and research into the pathological mechanisms of thrombotic disorders.

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SKU: 70681136643

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4.8 ★★★★★
Based on 6 reviews
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Product Reviews
A
Verified Purchase
Amazon Customer
Alexandria, US
★★★★★ 5
Great for aggressive chewers!
Size: Jumbo, Style: Peanut Butter
I have a very very aggressive chewer. She is a Rottweiler/Pitbull mix. Most toys she completely destroys within 2 days, sometimes 2 hours. I must praise this toy as she has had it for over 5 months and has not destroyed it! She loves chewing the ends and carries in her mouth squeaking it as she goes. I have 4 pups and they all take turns chewing when they can. I will be buying more Playology dog toys in the future. Thank you for making such a great toy!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
S
Verified Purchase
Steven Turner
Belleville, US
★★★★★ 5
They are her favorites
Size: Medium (VALUE 2-Pack), Style: Beef, Size: Medium (VALUE 2-Pack), Style: Beef
We’ve had many dogs, many very destructive ones and wish I had these years ago. The hard toys get sharp edges, this toy is the best and yes is far better than the other red ones. My bulldog wants tug of war for 30 min to an hour every night. We’ve gotten tennis elbow, tendinitis, and pulled muscles holding onto this thing. She has tons of toys but 9pm and this is only option for her. We don’t get a choice. Easy to hold, well for a few min until your hand gets tired. First you one was about 3 years ago and she’s only on her third one. They last forever, easy to clean, and aren’t sharp edges. Seriously, better than any toy sold anywhere. My phone has hundred of pictures of Pickle holding this. She’s doing it right now. If you have a strong destructive dog that takes pride in destroying toys, ruin their confidence and get them this one.
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Reviewed in the United States on April 5, 2026
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Verified Purchase
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Bozeman, US
★★★★★ 5
Perfect Toy for Large Dogs
Size: Medium, Style: Cheddar Cheese
I don’t normally leave reviews, but this toy is stellar and is a new favorite for my dog! She is a large dog (70lbs cattle dog lab mix) and I accidentally bought a medium, but it actually is a great size for her! So far this stands up to her chewing, but I may need to update in a few weeks to speak for durability but it really does feel solid. Most toys don’t last an afternoon once she starts chewing, so this has already won in that regard. The shape is perfect as well. She can gnaw at it, squeak, play fetch, play tug. It bounces when she throws it around herself. The fact it smells like stinky cheese is just an added bonus for her. All around, a very well designed dog toy!
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Reviewed in the United States on December 27, 2023
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Verified Purchase
Aly
Omaha, US
★★★★★ 4
Boxer Baby’s Favorite
Size: Jumbo, Style: Beef
This toy is my sweet girl’s absolute favorite. It was the first thing we gave her when we brought her home, and she has been obsessed with it since. She brings it from room to room, inside and outside. I would highly recommend this toy, however, we have gone through six in one year. They’re not very durable, especially with our boxer mix, who is a very heavy chewer. I’ve gotten the red and the blue, and she will only take red, which is fine with me because the blue STINKS. The red stinks too, but less so. The squeak is very loud, but she genuinely loves it so much that it’s hard to be annoyed by it. I’d say give the toy a try, you may be unintentionally giving them their favorite thing ever lol.
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Reviewed in the United States on October 2, 2025
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Verified Purchase
Renia
Natrona Heights, US
★★★★★ 1
Design Hazard
Size: Medium, Style: Bacon, Size: Medium, Style: Bacon
I have one of these in a larger version I picked up at the petstore. This one I do not recommend. There is a whole in the center where the pet bites down and my doggies' teeth kept getting stuck in it. If you've ever had a toy get stuck in your pups mouth, you've seen how thet go nuts trying to get it out.
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Reviewed in the United States on April 18, 2026

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