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Description
Histone H3 (Lactyl K18) Recombinant Rabbit mAb (S-3217-72)Product Specification Host Rabbit Antigen Histone H3 (Lactyl K18) Synonyms H3K18la Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 3217 72 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa treated with 100 mM Lactate sodium for 24 hours, NIH 3T3 treated with 100 mM Lactate sodium for 24 hours Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (Lactyl K18) |
| Synonyms | H3K18la |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-3217-72 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa treated with 100 mM Lactate sodium for 24 hours, NIH/3T3 treated with 100 mM Lactate sodium for 24 hours |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000-1:2000 | Hu, Ms |
| ICC | 1:500 | Hu, Ms |
Background
Histone H3 (Lactyl K18) refers to a specific post-translational modification on the 18th lysine residue (K18) of the histone H3 protein, where a lactate-derived lactyl group is covalently attached. Discovered as part of the broader "histone lactylation" mechanism, this epigenetic mark serves as a direct metabolic sensor that links cellular glycolysis and lactate production to gene regulation. Unlike traditional acetylation, which is often associated with general transcriptional activation, H3K18 lactylation (H3K18la) is particularly enriched during specific physiological states such as the late phase of macrophage polarization (driving the transition from pro-inflammatory M1 to reparative M2 phenotypes), hypoxia, and intense exercise. By recruiting specific reader proteins or altering chromatin accessibility at promoter and enhancer regions, H3K18la facilitates the expression of genes involved in tissue repair, angiogenesis, and metabolic adaptation, thereby establishing a crucial mechanistic bridge between cellular metabolism (the Warburg effect or high glycolytic flux) and the epigenetic control of cell fate and function.
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