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Description
Invivo anti-Rat TCR γ/δ Recombinant mAbProduct Specification Host Mouse Antigen TCR Location Cell membrane Accession A0A8I6G2Y5 Clone Number S 3864 Antibody Type Mouse mAb Application FCM, in vivo T cell depletion Reactivity Rt Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 2 to 8 C for 2 weeks under sterile
Product Specification
| Host | Mouse |
| Antigen | TCR γ/δ |
| Location | Cell membrane |
| Accession | A0A8I6G2Y5 |
| Clone Number | S-3864 |
| Antibody Type | Mouse mAb |
| Application | FCM, in vivo γ/δ T cell depletion |
| Reactivity | Rt |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
TCR γ/δ protein is a heterodimeric receptor—composed of one γ and one δ chain, each with a variable (V) and constant (C) immunoglobulin-like domain plus a short cytoplasmic tail—whose extracellular V regions recognize phosphoantigens, stress molecules or butyrophilin family ligands without MHC restriction, while its membrane-proximal C regions associate with CD3δε, γε and ζζ signaling modules; upon ligand binding the γ/δ chains undergo conformational change that exposes CD3 ITAMs to Lck-mediated phosphorylation, recruiting ZAP-70 and triggering a Vav1–PLC-γ1 cascade that elevates intracellular Ca²⁺, activates PKC-θ, NFAT, NF-κB and AP-1, and thereby drives γδ T-cell cytotoxicity, cytokine release and tumor lysis.
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