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Description
Trem2 Recombinant Rabbit mAb (S-2471-34)Product Specification Host Rabbit Antigen Trem2 Synonyms Triggering receptor expressed on myeloid cells 2; TREM 2; Triggering receptor expressed on monocytes 2; Trem2a; Trem2b; Trem2c Immunogen Recombinant Protein Location Cell membrane Accession Q99NH8 Clone Number S 2471 34 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Ms Positive Sample J774A. 1, RAW264. 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Trem2 |
| Synonyms | Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; Trem2a; Trem2b; Trem2c |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q99NH8 |
| Clone Number | S-2471-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Ms |
| Positive Sample | J774A.1, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| ICC | 1:100 | Ms |
Background
TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a ~40 kDa single-pass type I transmembrane glycoprotein of the immunoglobulin superfamily that is almost exclusively expressed by microglia in the brain, where together with its signaling adaptor DAP12 it forms a receptor complex that upon binding anionic lipids, apolipoprotein E, or aggregated β-amyloid initiates phosphorylation cascades that regulate microglial survival, proliferation, metabolic reprogramming toward glycolysis and oxidative phosphorylation, and phagocytosis of apoptotic neurons and extracellular plaques, thereby maintaining central nervous system homeostasis; genetic loss-of-function variants strongly increase the risk of Alzheimer’s disease, and its ectodomain is proteolytically cleaved by ADAM10 and ADAM17 to release a soluble fragment (sTREM2) that is elevated in cerebrospinal fluid in early AD and can itself act as an immunomodulatory ligand amplifying microglial responses to pathology.
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