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Description
MLH1 Recombinant Rabbit mAb (SDT-112-50-2)Product Specification Host Rabbit Antigen MLH1 Synonyms DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2 Immunogen Synthetic Peptide Location Nucleus Accession P40692 Clone Number SDT 112 50 2 Antibody Type Recombinant mAb Application WB, ICC Reactivity Hu Predicted Reactivity Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | MLH1 |
| Synonyms | DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P40692 |
| Clone Number | SDT-112-50-2 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC |
| Reactivity | Hu |
| Predicted Reactivity | Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:50 |
Background
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. MLH1 protein is one component of a system of seven DNA mismatch repair proteins that work coordinately in sequential steps to initiate repair of DNA mismatches in humans [PMID: 18543306]. Defects in mismatch repair, found in about 13% of colorectal cancers, are much more frequently due to deficiency of MLH1 than deficiencies of other DNA mismatch repair proteins [PMID: 15887099]. The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2 [ PMID: 18543306].
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