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Description
Biotin Mouse Anti-Human CD266 (TWEAK Receptor) Antibody (S-3902)Product Specification Host Mouse Antigen CD266 (TWEAK Receptor) Synonyms Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor inducible immediate early response protein 14 (FGF inducible 14); Tweak receptor (TweakR); FN14; TNFRSF12A Location Membrane Accession Q9NP84 Clone Number S 3902 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein A Concentration 0. 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD266 (TWEAK Receptor) |
| Synonyms | Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14); Tweak-receptor (TweakR); FN14; TNFRSF12A |
| Location | Membrane |
| Accession | Q9NP84 |
| Clone Number | S-3902 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD266, also known as the TWEAK receptor (TWEAK-R) or fibroblast growth factor–inducible 14 (Fn14), is a ~14 kDa type I transmembrane glycoprotein of the TNF receptor superfamily (TNFRSF12A) that contains no death domain but is expressed at low levels in many normal tissues (heart, placenta, lung, muscle, pancreas) and at high levels on activated endothelial cells and multiple tumor lines, where it binds the cytokine TWEAK (CD255) and recruits cytoplasmic TRAF1, TRAF2 and TRAF3 to activate canonical and non-canonical NF-κB pathways, thereby regulating context-dependent processes including inflammation, endothelial proliferation and angiogenesis, hepatocyte growth during liver regeneration, and either survival or apoptosis of epithelial and malignant cells.
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