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Description
S-RMab® EpCAM Recombinant Rabbit mAb,PBS Only (SDT-078-13)Product Specification Host Rabbit Antigen EpCAM Synonyms Adenocarcinoma associated antigen, Cell surface glycoprotein Trop 1, Epithelial cell surface antigen, Epithelial glycoprotein (EGP), Epithelial glcoprotein 314 (EGP314; hEGP314), GA733 2, M1S2, M4S1, MIC18, TACSTD1, TROP1, Ber EP4 Immunogen Synthetic Peptide Accession P16422 Clone Number SDT 078 13 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IF Reactivity Hu Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | EpCAM |
| Synonyms | Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein (EGP), Epithelial glcoprotein 314 (EGP314; hEGP314), GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1, Ber-EP4 |
| Immunogen | Synthetic Peptide |
| Accession | P16422 |
| Clone Number | SDT-078-13 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 | |
| ICC | 1:100 | |
| IF | 1:200 |
Background
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.
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Exchange/Return Notes
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