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Description
Alexa Fluor®488 Rat Anti-Mouse CD4 Antibody (S-R382)Product Specification Host Rat Antigen CD4 Synonyms T cell surface glycoprotein CD4; T cell differentiation antigen L3T4; T cell surface antigen T4 Leu 3; Cd4 Location Cell membrane Accession P06332 Clone Number S R382 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1%
Product Specification
| Host | Rat |
| Antigen | CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; Cd4 |
| Location | Cell membrane |
| Accession | P06332 |
| Clone Number | S-R382 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD4 is a glycoprotein that functions as a co-receptor for the T-cell receptor (TCR) and is primarily expressed on the surface of helper T cells, monocytes, macrophages, and dendritic cells. It is a member of the immunoglobulin superfamily, consisting of four immunoglobulin domains (D1 to D4) that interact with MHC class II molecules on antigen-presenting cells. This interaction, mediated by the D1 domain of CD4, ensures that T cells recognize antigens presented by MHC II. The cytoplasmic tail of CD4 contains motifs that recruit the tyrosine kinase Lck, which amplifies T cell activation signals. Additionally, CD4 is crucial in the immune response, as it helps activate CD4+ T helper cells, which in turn stimulate other immune cells to combat infections. However, CD4 is also the primary receptor for HIV, allowing the virus to enter host T cells and cause immunodeficiency.
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4.4 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
Our Yorkie Puppy Loves This Toy!!!
Color: Red
Warning: your pet may become completely obsessed
I’ve had this toy for about a year for my Yorkshire Terrier, Gia, and it’s easily the most successful toy purchase I’ve ever made. We even had to replace the first one after she loved it a little too much (chewed the string off), and have since bought more as gifts for friends’ pets. Great toy for small dogs (too fragile for bigger dogs) and active, young cats.)
What we love:
* Endless engagement: Gia ignores all her other toys and goes straight for this every time
* Interactive features: Subtle beeping + changing colored lights + unpredictable rolling patterns keep her hooked
* Energy burner: Perfect for indoor play on hardwood floors—she will chase it nonstop
* Rechargeable: Battery lasts several hours, even with frequent use
* Durability: Holds up well considering how rough she plays
Real-life note:
Gia will literally bring this toy to me to get me involved—and I have to limit her playtime because she won’t stop on her own.
Bottom line:
If you have a high-energy dog (or even a playful cat), this isn’t just a toy—it becomes their favorite activity… and possibly their entire personality.
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Reviewed in the United States on April 25, 2026
★★★★★ 5
This is a great ball for high energy dogs.
Color: Blue
I have a Belgian Malinois, so you can imagine the Maligator jaws. Just opened this today and let her play with it indoors. She LOVES IT. It wore her out and it’s a toy she can really stay focused on without needing me to throw or roll for her. It moves on its own! I supervised her play. I was hoping it was too big to get under the couch, but no. It goes right under it. I had to block off the gap so I didn’t have to keep getting it out from under for her. The outter “shell” is very durable! When she had resting moments, she chewed it pretty good - I could hear the material squeaking against her teeth. I was worried she was tearing it up, but nope! Not a mark on it. It’s easy to set up and operate. It needed charging before play. After hours of play, she was able to somehow unscrew the outter shell. This concerned me bc the smaller, inner ball mechanism came out but I saw it right away and was able to put it back together. So, make sure it’s screwed together tightly (which I thought I had done without breaking it) and check it from time to time to make sure it hasn’t loosened. This is a great ball for her incredible high energy drive. It gives her the work and fun play she needs to get tired, which I love. This toy is on the expensive end, but so far it’s worth it. Now we’ll see how long it lasts!
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Reviewed in the United States on October 7, 2025
★★★★★ 5
Love love it
Color: Blue
Best dog toy ever. I have a 1 year old boxer who is full of energy (understatement). This ball has provided more entertainment for us both than any dog toy I’ve ever purchased. Charge holds well and has a very resilient shell. I love it. Worth the price.
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Reviewed in the United States on May 23, 2026
★★★★★ 4
Great ball for limited entertainment. Replaceable outer shell is an amazing option!
Color: Blue, Color: Blue
Bought this for our 45lb, ball-obsessed Dutch shepherd/pit bull dog mix. I had one of these years ago with the hard shell and couldn’t be happier with the new foam shell.
The new foam shell is much quieter and while our dog might put holes in it with his teeth, he doesn’t seem to ever pull pieces off.
For engagement level, he found it VERY interesting at first and was scared to grab it, but once he got over that he started holding it in his mouth even when it shakes and just tries to keep it.
Isn’t the best for fetch or anything as he has trouble letting it go when it is actively moving, but it makes him happy while he has it. We just make sure to monitor him while it is out.
The ability to change the outer shell and just buy a replacement for the shell instead of a whole new toy is a lovely feature that makes me very happy to continue buying from this company.
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Reviewed in the United States on April 19, 2026
★★★★★ 5
Great Interactive Option
Color: Blue
To start, I have been very happy with this purchase. A couple of key points for me are durability and being able to keep my dog's attention. I have had it for almost a year, just a month shy, and she hasn't managed to get through the foam outer shell even though she tries real hard to do so. Let's just say, she's hard to find toys for because of her habit of finding the point of failure where she can pick and gnaw at until the toy is no longer safe for her to have. With this toy, she not only found her match, but it also has her watching, waiting, and even stalking. Only one small issue has recently occurred: the motor has started having an issue where the charge doesn't hold, and it doesn't remain on afterwards. I have reached out to Cheerble directly to see about replacing it since I am still within their 12-month timeframe, and they responded right away.
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Reviewed in the United States on April 22, 2026
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