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Description
KGF/FGF-7 Protein, HumanProduct Specification Species Human Synonyms Fibroblast growth factor 7, FGF 7, Heparin binding growth factor 7 (HBGF 7), Keratinocyte growth factor Accession P21781 Amino Acid Sequence Cys32 Thr194 Expression System E. coli Molecular Weight 20 22 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1
Product Specification
| Species | Human |
| Synonyms | Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7 (HBGF-7), Keratinocyte growth factor |
| Accession | P21781 |
| Amino Acid Sequence | Cys32-Thr194 |
| Expression System | E.coli |
| Molecular Weight | 20-22 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Am J Transplant. 2021 Sep;21(9):2950-2963. |
Background
Human fibroblast growth factor 7 (FGF-7) is also known as keratinocyte growth factor (KGF). It is a secreted, heparin-binding glycoprotein of 194 amino acids that belongs to the FGF family. FGF-7 is produced exclusively by mesenchymal cells and acts in a paracrine manner on epithelial cells expressing the splice variant FGFR2-IIIb. Upon ligand binding, the receptor dimerizes and initiates downstream signaling through the MAPK/ERK, PI3K/AKT and PLCγ pathways, leading to proliferation, migration, differentiation and survival of epithelial cells. Expression of FGF-7 is strongly up-regulated after skin, lung, kidney or gastrointestinal injury by inflammatory cytokines such as IL-1 and TNF-α, making it a key mediator of wound healing and tissue repair.
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