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Description
CD133 Recombinant Rabbit mAb, PBS Only (SDT-1295-22)Product Specification Host Rabbit Antigen CD133 Synonyms Prominin 1; Antigen AC133; Prominin like protein 1; PROM1; PROML1 Immunogen Recombinant Protein Location Cell membrane Accession O43490 Clone Number SDT 1295 22 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date
Product Specification
| Host | Rabbit |
| Antigen | CD133 |
| Synonyms | Prominin-1; Antigen AC133; Prominin-like protein 1; PROM1; PROML1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | O43490 |
| Clone Number | SDT-1295-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC-P | 1:1000 |
Background
CD133, also known as Prominin-1, is a pentaspan membrane glycoprotein expressed on the surface of various stem cells and cancer stem cells (CSCs). It plays a crucial role in tumorigenesis, metastasis, recurrence, and drug resistance, and is involved in the regulation of cellular energy metabolism, affecting glucose uptake, autophagy, and ATP synthesis. Moreover, the function of CD133 is not limited to cancer cells; it is also expressed in differentiated cells and stem/progenitor cells in normal tissues and is involved in multiple cellular processes, coordinating signaling pathways that are often deregulated in cancer, such as the PI3K/Akt signaling and Wnt/β-catenin pathways.
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Exchange/Return Notes
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