SKU: 80279963891

RORγt Recombinant Mouse mAb (S-4205)

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Description

RORγt Recombinant Mouse mAb (S-4205)Product Specification Host Mouse Antigen RORt Synonyms Nuclear receptor ROR gamma; Nuclear receptor RZR gamma; Nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; Retinoid related orphan receptor gamma; NR1F3; RORG; RZRG; RORC Location Nucleus Accession P51449 Clone Number S 4205 Antibody Type Mouse mAb Isotype IgG2b,k Application WB Reactivity Hu, Ms, Rt Positive Sample mouse thymus, rat thymus Purification Protein A

Product Specification


Host Mouse
Antigen RORγt
Synonyms Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; NR1F3; RORG; RZRG; RORC
Location Nucleus
Accession P51449
Clone Number S-4205
Antibody Type Mouse mAb
Isotype IgG2b,k
Application WB
Reactivity Hu, Ms, Rt
Positive Sample mouse thymus, rat thymus
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

RORγt is a DNA-binding transcription factor of the nuclear-receptor superfamily that serves as the master lineage-defining factor for Th17 cells, ILC3s, and other IL-17-producing lymphocytes, where it integrates cholesterol-derived oxysterol signals to drive the transcription of IL-17A/F, IL-22, and related pro-inflammatory genes, thereby orchestrating mucosal host defense against extracellular bacteria and fungi while also controlling circadian gene networks, lymphoid-organ development, and Treg/Th17 balance, making its activity—tunable by small-molecule agonists or inverse agonists—a pivotal rheostat in autoimmune, neoplastic, and infectious disease pathogenesis.

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Exchange/Return Notes
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SKU: 80279963891

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4.9 ★★★★★
Based on 30 reviews
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Product Reviews
J
Verified Purchase
Just My 2 Cents
Port Orchard, US
★★★★★ 5
Love denim and tired of cropped jackets?
Fit Type: Oversized, Size: Large, Color: Medium Blue Vintage
I like this a lot, it was what I was looking for as far as I'm so over everything you buy these days is cropped. Cropped styles are great, but are kind of getting old for some things in my opinion. The jacket is big as far as how it fits. I am 5'8" about 180 and I wish I would have got a medium, I got a large. The large is big and roomy enough that I could even wear ear a thick hoodie under it if I wanted to. However, the length is good as what I was looking for. The upper arms are large. However, this is a great quality denim jacket. Nice and thick, sturdy material (which I wanted). It's also at a great, competitive low price even if it's not on sale. Don't believe me, go ahead and search jean jackets. You'll see a ton, but I looked too and the quality did not look as good as this and plus the other jackets were a lot more for a lot less. If you're looking for a longer jean jacket, I highly recommend this. I'd say just think seriously about sizing down 1... even maybe 2 sizes. I would have gotten an XL before I read the other reviews. They recommended to size down, and after getting my jacket I could have sized down to a medium. I'm still happy with it and this is a jacket that is stitched well and will last a very long time. As always though, that's just my 2 cents. :)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 19, 2026
B
Verified Purchase
Briana C.
Birmingham, US
★★★★★ 4
Nice quality, shape not for me
Fit Type: Oversized, Size: Medium, Color: Medium Blue Vintage
This was just too boxy for my body. Material was nice, quality jean material. Color was true to image. It was a little stiff but as you would expect with nice, new and unwashed denim.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026
M
Verified Purchase
M1so
Cuba, US
★★★★★ 5
Solid basic good denim jacket
Fit Type: Regular, Size: X-Large, Color: Authentic Medium Wash
In direct comparison to Levi’s women’s trucker denim jacket, this one is: slightly heavier denim, less stretchy, less fitted. I kept this one and returned the Levi’s because I wanted the roomier fit. I wish it was a little longer in the body: I’m tall, and it isn’t too short but I’d like a little more length. It feels slightly longer than the Levi’s. I wish the sleeves were longer too. They are probably just right for an average height or shorter person. The armholes could be smaller. The medium wash is a nice medium blue, fairly even in tone. It doesn’t have a lot of stretch but it’s comfortable. The denim is substantial but not too stiff. Overall, it’s a standard good quality denim jacket without any peculiar style elements or weird cut. It’s good!
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Reviewed in the United States on April 3, 2026
M
Verified Purchase
Maryland Marcy
Birmingham, US
★★★★★ 3
Fabric way to heavy.
Fit Type: Regular, Size: Medium, Color: White
Cute, but material is WAY to heavy, like the heaviest duty denim I've ever seen. Wanted this to be a cute coverup. If you're needing something while breaking broncos or riding your motorcycle would probably be great. I kept it for a while because it was good quality and well made, but it ended up in the donation pile as I'd never wear this.
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Reviewed in the United States on June 10, 2026
C
Verified Purchase
Clare Lukes
Port Orchard, US
★★★★★ 5
Awesome jacket
Fit Type: Regular, Size: Medium, Color: Stone Dark Wash
Love it so not too long or too short but just right and the color is out of sight and fits awesome
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Reviewed in the United States on June 12, 2026

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