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Description
IL-6R alpha/CD126 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms IL6R,IL 6R 1,IL 6RA,IL6RA,IL6RQ,gp80 Amino Acid Sequence Leu20 Glu357 with hIgG1 Fc at C Terminus Expression System HEK293 Molecular Weight 80 95 kDa (Reducing) Purity >95% by SDS PAGE, >90% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Huamn IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS PH7. 4 5% trehalose Stability & Storage 12 months from date of receipt, lyophilized
Product Specification
| Species | Mouse |
| Synonyms | IL6R,IL-6R-1,IL-6RA,IL6RA,IL6RQ,gp80 |
| Amino Acid Sequence | Leu20-Glu357 with hIgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-95 kDa (Reducing) |
| Purity | >95% by SDS-PAGE, >90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Huamn IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51. |
Background
The IL-6 receptor (IL-6R/CD126) is a type-I cytokine receptor formed by an 80 kDa ligand-binding subunit (IL-6Rα) and a 130 kDa signal-transducing subunit (gp130). gp130 is ubiquitous, whereas IL-6Rα is confined mainly to hepatocytes and immune cells. IL-6 signaling occurs via two routes: classical signaling through membrane-bound IL-6Rα and trans-signaling mediated by soluble IL-6R (sIL-6R) generated through proteolytic cleavage or alternative splicing; sIL-6R enables IL-6 to activate gp130 on cells that lack membrane IL-6Rα, thereby broadening its biological impact. Dysregulation of this pathway drives chronic inflammation (e.g., rheumatoid arthritis, Crohn’s disease) and promotes malignancies such as multiple myeloma, making the receptor a validated therapeutic target—anti-IL-6R antibodies have shown clinical efficacy. The extracellular region of IL-6Rα contains conserved Ig-like and fibronectin type-III domains bearing the WSXWS motif, underscoring its functional importance across species despite minor species-specific processing differences.
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