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Description
Invivo Anti-Human CD71 Recombinant mAbProduct Specification Host Mouse Antigen CD71 Synonyms Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; TFRC Location Secreted, Cell membrane Accession P02786 Clone Number S 3801 Antibody Type Recombinant mAb Application ELISA, WB Reactivity Hu Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no
Product Specification
| Host | Mouse |
| Antigen | CD71 |
| Synonyms | Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; TFRC |
| Location | Secreted, Cell membrane |
| Accession | P02786 |
| Clone Number | S-3801 |
| Antibody Type | Recombinant mAb |
| Application | ELISA, WB |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| IHC-P | 1:1000-1:5000 | Hu |
Background
CD71, also termed transferrin receptor-1 (TFRC), is a 95-kDa type-II transmembrane glycoprotein that forms a disulfide-linked homodimer and serves as the master mediator of cellular iron uptake by binding two molecules of iron-loaded transferrin, triggering clathrin-dependent endocytosis whose efficiency is heightened in the low-pH endosome where iron is released, after which the receptor–ligand complex is recycled back to the surface; the protein is almost ubiquitously expressed but most abundant on rapidly dividing, erythroid, placental, neuronal and malignant cells whose proliferative and metabolic demand for iron keeps CD71 transcriptionally and post-transcriptionally up-regulated, while its apical domain additionally binds ferritin, selected viruses and therapeutic nanocarriers, making CD71 a key determinant of erythropoiesis, a biomarker of iron status and tumor burden, and a validated gateway for drug delivery and viral entry.
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