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Description
VE-Cadherin Recombinant Rabbit mAb (S-1291-239)Product Specification Host Rabbit Antigen CD144 Synonyms Cadherin 5; 7B4 antigen; Vascular endothelial cadherin (VE cadherin); CDH5 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P33151 Clone Number S 1291 239 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Ms, Rt Positive Sample mouse heart, rat heart Predicted Reactivity Pg, Ck Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | CD144 |
| Synonyms | Cadherin-5; 7B4 antigen; Vascular endothelial cadherin (VE-cadherin); CDH5 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P33151 |
| Clone Number | S-1291-239 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Positive Sample | mouse heart, rat heart |
| Predicted Reactivity | Pg, Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:2000 | Ms, Rt |
Background
CD144, also termed VE-cadherin or cadherin-5, is a 140 kDa calcium-dependent type-II classical cadherin expressed almost exclusively on vascular and lymphatic endothelial cells, where it forms the core of adherens junctions by mediating homophilic trans-interactions between neighboring cells and anchoring to the actin cytoskeleton via catenins (β-, γ-, and p120-catenin), thereby controlling endothelial barrier integrity, vascular permeability, leukocyte extravasation, and embryonic angiogenesis, while also modulating VEGF receptor signaling, cell polarity, and lumen formation.
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Exchange/Return Notes
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