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Description
CD300g/Nepmucin/CLM9 His Tag Protein, HumanProduct Specification Species Human Synonyms CMRF35 Like Molecule 9; CLM 9; CD300 Antigen Like Family Member G; Triggering Receptor Expressed on Myeloid Cells 4; TREM 4; CD300g; CD300LG; CLM9; TREM4 Accession Q6UXG3 1 Amino Acid Sequence Leu19 Arg247, with C terminal His Expression System HEK293 Molecular Weight 35 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder
Product Specification
| Species | Human |
| Synonyms | CMRF35-Like Molecule 9; CLM-9; CD300 Antigen-Like Family Member G; Triggering Receptor Expressed on Myeloid Cells 4; TREM-4; CD300g; CD300LG; CLM9; TREM4 |
| Accession | Q6UXG3-1 |
| Amino Acid Sequence | Leu19-Arg247, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 35-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Umemoto, E. et al. (2013) PloS One. 8:e83681. 2.Umemoto, E. et al. (2006) J. Exp. Med. 203:1603. 3.Takatsu H, et al. (2006) Biochem. Biophys. Res. Commun. 348:183. |
Background
Nepmucin, also known as CMRF35-like molecule 9 (CLM-9), TREM-4 and CD300g, is a 75-95 kDa type I transmembrane O-glycosylated member of the CD300 family of molecules. Nepmucin plays a critical role in promoting lymphocyte transendothelial migration of high endothelial veins and mediates lymphocyte adhesion with endothelial cells by its Ig domain, which is independent of LFA-1 or VLA-4 adhesion pathway. Glycosylated nepmucin with MECA-79 epitope associate with L-selectin to mediate L-selectin-dependent lymphocyte rolling by its mucin-like domain. Expression of nepmucin is down-regulated in tumours and tumour-draining lymph nodes, indicating that the expression of nepmucin is negatively regulated by locally produced signals under these circumstances. Nepmucin induction can significantly improve the killing activity of CIK cells.Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner.
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