SKU: 82466667673

GFRAL Fc Chimera Protein, Human

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Description

GFRAL Fc Chimera Protein, HumanProduct Specification Species Human Synonyms GFR alpha like,GRAL,GDNF family receptor alpha like Accession Q6UXV0 Amino Acid Sequence Ser19 Glu351 with Human IgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 60 80kDa (Reducing) Purity 95% by SDS PAGE &SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according

Product Specification


Species Human
Synonyms GFR alpha like,GRAL,GDNF family receptor alpha-like
Accession Q6UXV0
Amino Acid Sequence

Ser19-Glu351 with Human IgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

60-80kDa (Reducing)
Purity ＞95% by SDS-PAGE &SEC-HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
· Please avoid repeated freeze-thaw cycles.
Reference

1.Airaksinen MS, Holm L, Hätinen T. Evolution of the GDNF family ligands and receptors. Brain Behav Evol. 2006;68(3):181-90.
2.Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med. 2017 Oct;23(10):1215-1219.

Background

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFbeta) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 82466667673

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4.6 ★★★★★
Based on 21 reviews
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Product Reviews
F
Verified Purchase
freespirit426
Alexandria, US
★★★★★ 5
Big Toy Rabbit
My Mini Aussie loves this toy, she is obsessed with toy bunnies. It holds up well.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 1, 2026
S
Verified Purchase
💞Strange💞
Chelsea, US
★★★★★ 5
Dog loves the bunny
This is a real rabbit-sized toy, and my dog loves it. One of the squeakers makes an animal grunting sound, which again, my dog loves (and I find a little unnerving). These are not built to last, though for my aggressive chewer, they hold up surprisingly well. It usually takes her about two weeks to thoroughly dismember and disembowel one. Of course, if I get involved in a spirited tug-of-war with my dog and the bunny, the rabbit doesn't last very long, but the bunny survives surprisingly well for our normal playing (I toss it up in the air, she catches it and takes it to her blanket to chew on it for a bit). I don't know of ANY plush toys that will last more than a couple of weeks at best, even the Kong Knots (which she also likes). Most, however, seem to disintegrate within minutes under her attention, so I love finding plush toys that my pup can play with for a while!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 15, 2020
B
Verified Purchase
Bryan
Chelsea, US
★★★★★ 3
My dog absolutely loves it, but durability is poor.
This is my dog's second Pet Lou bunny. The first one I picked up in some random store. I tied it onto the end of my home-made flirt pole (look it up). She absolutely loves this toy. Her favorite has to be the squeakers in each paw. She likes the grunter in the body fine, and doesn't seem to care for the crinkly ears. Since it was on a flirt pole and I do not let her play with it solo, it lasted a long time. After finally killing the last paw squeaker I thought I'd buy a replacement with the expectation that the new one would be as durable as the old. The very first time we played with the new bunny, it came away with 1 broken paw squeaker and a tear in an armpit. The squeakers I can understand because she is a major chewer, but the tear after 1 use leads me to believe these toys are not as durable or the quality control at the factory is poor.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2023
D
Verified Purchase
Dr. Michael Hfuhruhurr
Lake Worth, US
★★★★★ 5
A winner! Life size bunny that quacks.
It's the size of a real rabbit, and seems reasonably well made, and after a few weeks my dog hasn't exposed any stuffing. The ears have crinkly plastic in them, and the body has a duck-quack squeaker. My dog doesn't love crinkly plastic or high-pitched squeakers, but she loves this toy, and doesn't seem to mind that a rabbit quacks like a duck. My dog has shown a particular preference for this over her other stuffed toys, so I'd say it was a really good value, and would buy another without hesitation if something ever happens to this one.
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Reviewed in the United States on February 21, 2026
M
Verified Purchase
Mona
Natrona Heights, US
★★★★★ 5
Very well made and sturdy
Color: Carrot Orange
This toy isn’t quite indestructible but it is very sturdy and so far I’m pleased. I have a 5 month old who is a chewer and she has destroyed toys at a fast pace. It’s just the right size and weight for her to toss around, and I have thrown it in the washer inside a mesh bag once already. The fabric is soft, yet very strong. The only casualty to it was an ear. One had to be cut off once she had it partially chewed off. That’s a win in my book!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 30, 2026

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