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Description
S-RMab®B7-H3/CD276 Recombinant Rabbit mAb (SDT-R158)Product Specification Host Rabbit Antigen B7 H3 CD276 Synonyms B7 homolog 3, Costimulatory molecule Immunogen N A Location Membrane Accession Q5ZPR3 Clone Number SDT R158 Antibody Type Recombinant mAb Application IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20
Product Specification
| Host | Rabbit |
| Antigen | B7-H3/CD276 |
| Synonyms | B7 homolog 3, Costimulatory molecule |
| Immunogen | N/A |
| Location | Membrane |
| Accession | Q5ZPR3 |
| Clone Number | SDT-R158 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | null |
| ICFCM | 1:5000 | null |
| ICC | 1:500 | null |
Background
B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. Thus far, numerous B7-H3-based immunotherapy strategies have demonstrated potent antitumor activity and acceptable safety profiles in preclinical models [PMID: 34349762].
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