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Description
Human IGFBP-1, His TagProduct Specification Species Human Synonyms IBP 1, IGF binding protein 1, Placental protein 12 (PP12) Accession P08833 Amino Acid Sequence Protein sequence (P08833, Ala26 Asn259 with C 10*His) APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQNGGGGSHHHHHHHHHH Expression
Product Specification
| Species | Human |
| Synonyms | IBP-1, IGF-binding protein 1, Placental protein 12 (PP12) |
| Accession | P08833 |
| Amino Acid Sequence | Protein sequence (P08833, Ala26-Asn259 with C-10*His) APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQNGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 26.9kDa Actual: 30kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 ℃ to -70 °C as supplied. |
Background
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Serum IGFBP-1 provided high diagnostic accuracy of early-stage ESCC, EJA, stomach and cancer.
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4.8 ★★★★★
Based on 28 reviews
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Product Reviews
★★★★★ 5
Good for sensitive skin, zero fragrance, leaves skin soft and moisturized!
Size: 3 Fl Oz (Pack of 1)
I got this to go along with my Vanicream sensitive skin cleanser, and I'm very happy with it! It is a little more liquidy than cream-like, but it absorbs into skin well and leaves it feeling soft and moisturized. Great for sensitive skin and completely free of fragrance, with a shorter ingredient list that gives me more peace of mind. Very pleased with this, try it!
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Reviewed in the United States on May 23, 2026
★★★★★ 5
Great Value for a Good Moisturizer (5- Stars)
Size: 3 Fl Oz (Pack of 1)
This moisturizer contains nothing fancy — and that’s the whole point. The ingredients are few but effective, with several ceramides and hyaluronic acid for deep and long-lasting hydration. Best of all, it contains no silicones or parabens. Because it’s noncomedogenic, it doesn’t cause breakouts from clogged pores. Since I have sensitive skin, all of the above are critical for my skin care routine.
It’s about as simple and as effective as a cream can get. Because of that, it doesn’t contains any sunscreen, retinol, or other anti-wrinkle components.
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Reviewed in the United States on May 18, 2026
★★★★★ 5
Excellent facial moisturizer
Size: 3 Fl Oz (Pack of 1)
Very gentle, lightweight, absorbs well without feeling greasy or heavy. Perfect to use after Fraxel laser treatment. I also like it is fragrance free and really good on sensitive skin.
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Reviewed in the United States on May 6, 2026
★★★★★ 4
Medium weight minimal ingredient moisturizer!
Size: 3 Fl Oz (Pack of 1)
As with another review, I’m looking for a replacement/dupe for Eucerin Urea Repair face moisturizer which is 5% urea
Skin concerns: dry rosacea, mid-40s, arid climate with 4 seasons, winters are cold and snowy and summers are 90°+ for most.
This is a medium-weight moisturizer that I consider not greasy at all. It is not as hydrating as I need it to be for my dry skin type with rosacea. Thickness wise I say it is similar to a standard facial sunscreen.
It does last overnight, in the morning I can still feel it in some areas. I will try increasing how much I apply in order to see if it helps with how much staying power it has. This may increase the hydration it provides and I will update my review to report back.
I had a very mild stinging sensation but my rosacea is struggling since moving to a dry climate. Once I repair my skin barrier a bit, I fully expect this will cease.
Due to this, I’m not going to get my husband to try it, he has constantly broken skin from severe eczema and stinging is something that makes him not use moisturizers. It’s a battle!
For people in more humid climates this may be a more effective moisturizer, or those with less-dry skin than me. I never have flakes so this wasn’t a parameter for me.
There is no tint. I’m not sure about white cast so I can’t rate it for skin tone. But I don’t feel there would be, this seems translucent unless you really go in with it.
For me it is reasonably effective. It’s probably a good day moisturizer and I expect it plays well with sunscreen, though I would definitely let it absorb or dry down. Which is pretty standard for daytime skin care.
There is a slight grippy feeling when applying, but this dissipates like the Eucerin Urea Repair does.
This is not, for me, a replacement or dupe for Eucerin Urea Repair. It is a great value for the price!
Overall for someone with skin like mine I rate it a very solid 4/5. I would likely purchase again for a lightweight moisturizer as a more affordable substitute for Beauty Of Joseon Dynasty Cream for day. Though this does not give me the “bounce” that does. Alas.
Updated to add: I tried increasing the amount I apply, and that eliminated any grippy feeling when applying. I now apply both day and night and this has helped repair my barrier enough it doesn’t sting when I apply this. I still have a way to go before I can return to using my sunscreen, but I do work in a building with no windows so the few minutes I am outside, it’s okay if I go without.
If I apply this to my eyes, it doesn’t sting them, which is great, my eyes are extremely sensitive and I hesitated, but it works out just fine. It isn’t thick enough to cause whiteheads to form on my lids, unlike some balm-type moisturizers (LRP!) and even unfortunately Bioderma Sensibio Eye+
I have noticed the backs of my hands are improved as I wipe off excess onto the backs of my hands and into my cuticles. I was genuinely surprised by this, it’s not like I don’t wash my hands. I wasn’t expecting it to have any effect, but the stinging scaley hands are gone, now my hands just feel normal, even after wearing wool fingerless gloves all day at work.
I will continue to use this product and will repurchase even after my financial situation improves.
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Reviewed in the United States on October 19, 2025
★★★★★ 5
My rosacea approves
Size: 3 Fl Oz (Pack of 1)
I have Rosacea, dry, sensitive, reactive skin and perimenopausal skin. My rosacea products tends to dry my already dry skin and this has been been a great moisturizer. My skin looks dewy, dullness and dryness have improved in just 2 days; I haven't reacted with sting and redness like I usually do and when I wake up I still have a dewy not greasy face even though I sleep on my sides and toss and turn all night. Definitely going to buy again since the bottle size is good, a lil goes a long way and does not make my face react like the CeraVe.
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Reviewed in the United States on April 28, 2026
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