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Description
Phospho-TrkA(Tyr674/675)/TrkB(Tyr706/707) Recombinant Rabbit mAb (S-3359)Product Specification Host Rabbit Antigen Phospho TrkA (Tyr490) TrkB (Tyr516) Synonyms High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type; Tyrosine kinase receptor; TRK Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession P04629Q16620 Clone Number S 3359 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Rt Positive Sample Human Beta NGF treated PC 12 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | Phospho-TrkA (Tyr490)/TrkB (Tyr516) |
| Synonyms | High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type; Tyrosine kinase receptor; TRK |
| Immunogen | Synthetic Peptide |
| Location | Endosome, Cell membrane |
| Accession | P04629、Q16620 |
| Clone Number | S-3359 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Rt |
| Positive Sample | Human Beta-NGF treated PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Rt |
Background
Phospho-TrkA (Tyr490) and phospho-TrkB (Tyr516) are the neurotrophin-activated, autophosphorylated forms of the receptor tyrosine kinases TrkA and TrkB; once these juxtamembrane tyrosines are phosphorylated they serve as docking platforms for adaptor proteins—TrkA-pTyr490 recruits FRS2 and Shc to trigger Ras/MAPK and PI3K/Akt cascades that mediate neuronal survival and differentiation, whereas TrkB-pTyr516 binds Shc to activate the same pathways plus PLCγ-driven PKC and Ca²⁺ signals that regulate synaptic plasticity—so antibodies detecting these phospho-sites are widely used as biomarkers for NGF- or BDNF-dependent Trk signaling in health and disease.
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