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Description
Ku80 Recombinant Rabbit mAb (S-R226)Product Specification Host Rabbit Antigen Ku80 Synonyms X ray repair cross complementing protein 5, 86 kDa subunit of Ku antigen, ATP dependent DNA helicase 2 subunit 2, ATP dependent DNA helicase II 80 kDa subunit, CTC85, CTCBF, XRCC5, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid lupus autoantigen (TLAA) Location Nucleus, Nucleolus Accession P13010 Clone Number S R226 Antibody Type Recombinant mAb Application WB, IHC P, ICC,
Product Specification
| Host | Rabbit |
| Antigen | Ku80 |
| Synonyms | X-ray repair cross-complementing protein 5, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC85, CTCBF, XRCC5, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid-lupus autoantigen (TLAA) |
| Location | Nucleus, Nucleolus |
| Accession | P13010 |
| Clone Number | S-R226 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:500 | null |
| ICFCM | 1:500 | null |
| ICC | 1:500 | null |
| IP | 1:50 | null |
Background
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is required for telomere length maintenance and subtelomeric gene silencing. Ku80 protein expression was found to be deficient in melanoma. In addition, low expression of Ku80 was found in 15% of adenocarcinoma type and 32% of squamous cell type non-small cell lung cancers, and this was correlated with hypermethylation of the XRCC5 promoter.
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