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Description
Spink1 Recombinant Rabbit mAb (S-R249)Product Specification Host Rabbit Antigen Spink1 Synonyms Serine protease inhibitor Kazal type 1, Pancreatic secretory trypsin inhibitor, Tumor associated trypsin inhibitor (TATI), PSTI Location Secreted Accession P00995 Clone Number S R249 Antibody Type Recombinant mAb Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | Spink1 |
| Synonyms | Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor, Tumor-associated trypsin inhibitor (TATI), PSTI |
| Location | Secreted |
| Accession | P00995 |
| Clone Number | S-R249 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 | null |
Background
Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene. Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.
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