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Description
PDE4 Recombinant Rabbit mAb (S-2598-147)Product Specification Host Rabbit Antigen PDE4 Synonyms 3',5' cyclic AMP phosphodiesterase 4A; DPDE2; PDE46; cAMP specific phosphodiesterase 4A; PDE4A Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P27815 Clone Number S 2598 147 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, SH SY5Y, mouse brain, mouse cerebellum, rat brain, rat cerebellum Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | PDE4 |
| Synonyms | 3',5'-cyclic-AMP phosphodiesterase 4A; DPDE2; PDE46; cAMP-specific phosphodiesterase 4A; PDE4A |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P27815 |
| Clone Number | S-2598-147 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, SH-SY5Y, mouse brain, mouse cerebellum, rat brain, rat cerebellum |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:100 | Hu, Ms, Rt |
Background
PDE4 (phosphodiesterase-4) is a cAMP-specific phosphodiesterase that hydrolyzes the second messenger cyclic adenosine monophosphate (cAMP) to 5'-AMP, thereby terminating cAMP signaling cascades involved in inflammation, memory, cardiac contractility and immune cell regulation; the enzyme family comprises four subtypes (PDE4A-D) that differ in N-terminal targeting domains and regulatory Upstream Conserved Regions (UCR1/2) controlling dimerization and PKA-mediated phosphorylation, and selective inhibition of PDE4—for example with roflumilast or apremilast—elevates intracellular cAMP, suppressing pro-inflammatory cytokines (TNF-α, IL-23) and increasing anti-inflammatory IL-10, making PDE4 inhibitors clinically useful in psoriasis, psoriatic arthritis, Behçet’s disease and severe COPD.
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