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Description
Phospho-S6 Ribosomal Protein (Ser235/236) Recombinant Rabbit mAb (S-R203)Product Specification Host Rabbit Antigen Phospho S6 Ribosomal Protein (Ser235 236) Synonyms Phospho Small ribosomal subunit protein eS6 (Ser235 236), Phospho 40S ribosomal protein S6 (Ser235 236), Phospho Phosphoprotein NP33 (Ser235 236) Location Cytoplasm, Nucleus, Nucleolus Accession P62753 Clone Number S R203 Antibody Type Rabbit mAb Application WB, ICC, IP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Phospho-S6 Ribosomal Protein (Ser235/236) |
| Synonyms | Phospho-Small ribosomal subunit protein eS6 (Ser235/236), Phospho-40S ribosomal protein S6 (Ser235/236), Phospho-Phosphoprotein NP33 (Ser235/236) |
| Location | Cytoplasm, Nucleus, Nucleolus |
| Accession | P62753 |
| Clone Number | S-R203 |
| Antibody Type | Rabbit mAb |
| Application | WB, ICC, IP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:500 | |
| IP | 1:50 |
Background
Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis [PMID: 16166381, PMID: 16679021, PMID: 19479038]. p70S6K is a serine/threonine kinase that phosphorylates the S6 protein of the 40S ribosomal subunit (phosphorylated S6 ribosomal protein (phospho-S6rp)) at several sites, including serines 235 and 236, leading to initiation of protein synthesis [PMID: 16860938].
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