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Description
CLEC7A His Tag Protein, HumanProduct Specification Species Human Synonyms BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 Accession Q9BXN2 2 Amino Acid Sequence Thr 66 Met 201 with His Tag at the N Terminus Expression System HEK293 Molecular Weight 15 25kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2 |
| Accession | Q9BXN2-2 |
| Amino Acid Sequence | Thr 66 - Met 201 with His Tag at the N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 15-25kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. Alveolar macrophages drive lung fibrosis by sensing translocated gut fungi via Dectin-1-Raf1 axis. Immunity. |
Background
CLEC7A (C-type lectin domain family 7 member A) encodes the protein Dectin-1, a key member of the C-type lectin receptor family that functions as a pattern recognition receptor central to antifungal immunity. The gene is located on human chromosome 12p13.2 and is broadly expressed in tissues including bone marrow and appendix.
Structure and Isoforms: Dectin-1 is a type II transmembrane glycoprotein of approximately 28 kDa, containing an extracellular C-type lectin-like domain (CRD), a transmembrane region, and a cytoplasmic domain. The cytoplasmic tail harbors an immunoreceptor tyrosine-based activation motif (ITAM) essential for signal transduction. Alternative splicing generates at least eight isoforms (A-H), with isoform A representing the full-length functional form; isoform B lacks the stalk region, while others harbor deletions or insertions in the CRD or transmembrane domains.
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