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Description
4-1BB Ligand/TNFSF9 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms 4 1BB Ligand, TNFSF9, CD137L Accession P41273 1 Concentration 95% by SDS PAGE Amino Acid Sequence Arg71 Glu254, with N terminal Fc Expression System HEK293 Molecular Weight 43 55kDa (Reducing) Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose5% mannitol Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | 4-1BB Ligand, TNFSF9, CD137L |
| Accession | P41273-1 |
| Concentration | ＞95% by SDS-PAGE |
| Amino Acid Sequence | Arg71-Glu254, with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose，5% mannitol |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cancer Res.2019 Feb 15;79(4):783-794. |
Background
The 4-1BB ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that is part of the TNF superfamily. 4-1BBL is the high affinity ligand of 4-1BB. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD).
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