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Description
BTK Recombinant Rabbit mAb (SDT-2105-37)Product Specification Host Rabbit Antigen BTK Synonyms Tyrosine protein kinase BTK; Agammaglobulinemia tyrosine kinase (ATK); B cell progenitor kinase (BPK); Bruton tyrosine kinase; AGMX1; ATK; BPK; BTK Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Cell membrane Accession Q06187 Clone Number SDT 2105 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Raji, Daudi, Ramos, THP 1, RAW264.
Product Specification
| Host | Rabbit |
| Antigen | BTK |
| Synonyms | Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase (ATK); B-cell progenitor kinase (BPK); Bruton tyrosine kinase; AGMX1; ATK; BPK; BTK |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q06187 |
| Clone Number | SDT-2105-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Raji, Daudi, Ramos, THP-1, RAW264.7, A20 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that plays a crucial role in B-cell development and function. It is encoded by the BTK gene and consists of five distinct structural domains, including a kinase domain. BTK is essential for transmitting signals from B-cell antigen receptors, leading to processes like calcium mobilization and B-cell maturation. Mutations in the BTK gene can cause X-linked agammaglobulinemia (XLA), an immunodeficiency characterized by a lack of mature B cells and antibodies. In addition to its role in B cells, BTK is also involved in mast cell activation and has been implicated in various cancers, where its abnormal activation can lead to uncontrolled B-cell proliferation. Due to its involvement in B-cell signaling and cancer, BTK has become an important target for therapeutic interventions.
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