SKU: 92111350726

CD40/TNFRSF5 Fc Chimera Protein, Cynomolgus

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Description

CD40/TNFRSF5 Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with hIgG1 Fc Expression System HEK293 Molecular Weight 52 58kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence

Glu21-Arg193, with hIgG1 Fc

Expression System HEK293
Molecular Weight

52-58kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 92111350726

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Edith Mastrianni
Alexandria, US
★★★★★ 5
8 panel Room Divider is excellent quality
The GoFlame 8 Panel Room Divider is made with excellent material and the seller of this Divider is totally customer friendly. I highly recommend this company and this Divider if you are shopping for a room divider.
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Reviewed in the United States on April 25, 2026
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✧˖° Jeanne Lee ✧˖°
Belleville, US
★★★★★ 5
A Versatile and Elegant Solution for Room Separation
I recently purchased the GOFLAME 8 Panel Room Divider, and I'm thoroughly impressed with its quality and design. This room divider is not only a decorative element, but it also provides a practical solution for creating distinct areas within a room. Here's why I'm giving it a 5-star review: Enhanced Privacy Space: The 6 ft tall room divider is perfect for creating a private space within a larger room. It's ideal for my home office, and I can use it to separate my workspace from the rest of the room. The screen also creates a cozy and intimate atmosphere, making it perfect for relaxing or reading. Hand-woven Texture: The unique hand-woven texture of the room divider adds an element of sophistication and warmth to my room. The intricate craftsmanship is impressive, and it exudes artisanal charm. I love the way it looks, and it's become a conversation piece in my home. Built with Strength: The solid wood frame is sturdy and well-constructed, providing reliable support for the room divider. I'm impressed by the attention to detail and the quality of the materials used. Foldable Design and Easy Storage: The foldable design of the room divider makes it easy to store when not in use. I can simply fold the panels flat and store them away, which is convenient and space-saving. The metal hinges that connect the panels are also sturdy and well-made. No Assembly Required: I was pleasantly surprised to find that the room divider requires no assembly. I simply took it out of the box and set it up, and it was ready to use. The smooth woven surface is also easy to clean and maintain. Overall Impression: I'm thoroughly impressed with the GOFLAME 8 Panel Room Divider. It's a stylish and functional solution for creating a private space within a larger room. The hand-woven texture and solid wood frame add an element of sophistication and warmth, and the foldable design makes it easy to store. I
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Reviewed in the United States on September 14, 2024
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Beverly D Clark
West Palm Beach, US
★★★★★ 5
Quality product !
This is a quality lightweight room divider.! Actually is the second one of this type that I have bought. If you have an area that you just want to close off from the rest of the room, these work perfect!!!
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Reviewed in the United States on October 14, 2025
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chuande tang
Houston, US
★★★★★ 5
It suits me very well
I have a very large room. Its layout is perfect for me to convert into two rooms. Adding this screen is perfect and matches the style of my house.
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Reviewed in the United States on August 29, 2024
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Val
Natrona Heights, US
★★★★★ 5
True to Description
Color: Black, Size: 4 Panel
Love it!! I bought it for privacy while the nurse is dressing my dad. There were several colors black matched the decor . It blocked the sunlight and street lights. Durability and quality very good. Easy closure when not in use. Lightweight. No assembly needed
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Reviewed in the United States on May 29, 2026

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