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Description
Bc1-w His Tag Protein, HumanProduct Specification Species Human Synonyms Bcl 2 Like Protein 2; Bcl2 L 2; Apoptosis Regulator Bcl W; BCL2L2; BCLW; KIAA0271 Accession AAI13523. 1 Amino Acid Sequence Ala2 Thr172 Expression System E. coli Molecular Weight 19. 87 KDa Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7. 5. Stability & Storage Store at 70C, stable for 6 months
Product Specification
| Species | Human |
| Synonyms | Bcl-2-Like Protein 2; Bcl2-L-2; Apoptosis Regulator Bcl-W; BCL2L2; BCLW; KIAA0271 |
| Accession | AAI13523.1 |
| Amino Acid Sequence |
Ala2-Thr172
|
| Expression System | E.coli |
| Molecular Weight |
19.87 KDa
|
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5. |
| Stability & Storage |
|
Background
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
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