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Description
Klf4 Recombinant Rabbit mAb (S-2158-54)Product Specification Host Rabbit Antigen Klf4 Synonyms Krueppel like factor 4; Epithelial zinc finger protein EZF; Gut enriched krueppel like factor; EZF; GKLF; KLF4 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession O43474 Clone Number S 2158 54 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HT 29, HCT 116, MCF7, Ramos, HepG2, PC 3 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Klf4 |
| Synonyms | Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor; EZF; GKLF; KLF4 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | O43474 |
| Clone Number | S-2158-54 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HT-29, HCT 116, MCF7, Ramos, HepG2, PC-3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Klf4, also known as Krüppel-like factor 4, is a transcription factor that plays a crucial role in various biological processes. It is involved in cell differentiation, proliferation, and apoptosis, and is highly expressed in epithelial tissues such as the gastrointestinal tract and skin. Klf4 regulates the expression of numerous genes by binding to specific DNA sequences in their promoters, thereby modulating cellular functions. In the context of stem cell biology, Klf4 is one of the four Yamanaka factors used to reprogram somatic cells into induced pluripotent stem cells (iPSCs), highlighting its significance in cellular reprogramming and regenerative medicine. Additionally, Klf4 has been implicated in maintaining the integrity of the intestinal barrier and has potential implications in cancer development and progression, making it an important target for therapeutic interventions.
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