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Description
Argonaute 2 Recombinant Rabbit mAb (S-2620-13)Product Specification Host Rabbit Antigen Argonaute 2 Synonyms Protein argonaute 2; mAgo2; Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2 (eIF 2C 2; eIF2C 2); Piwi argonaute family protein meIF2C2; Protein slicer; Eif2c2; Kiaa4215; Ago2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q8CJG0 Clone Number S 2620 13 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu,
Product Specification
| Host | Rabbit |
| Antigen | Argonaute 2 |
| Synonyms | Protein argonaute-2; mAgo2; Argonaute RISC catalytic component 2; Eukaryotic translation initiation factor 2C 2 (eIF-2C 2; eIF2C 2); Piwi/argonaute family protein meIF2C2; Protein slicer; Eif2c2; Kiaa4215; Ago2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q8CJG0 |
| Clone Number | S-2620-13 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, MCF7, HepG2, U-87 MG, HCT 116, RAW264.7, mouse kidney, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
Argonaute 2 (AGO2) is the only catalytically active member of the four mammalian Argonaute proteins, acting as the core effector of RNA interference by loading ~22-nt microRNAs or siRNAs to form the RNA-induced silencing complex (RISC), in which its PIWI endonuclease domain can cleave perfectly complementary mRNAs while mismatched targets are repressed translationally via deadenylation and P-body sequestration; uniquely indispensable for vertebrate development, AGO2 also participates in transcriptional gene silencing, antiviral defense, and stress-granule dynamics, and its expression and post-translational modifications are frequently dysregulated in cancers .
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