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Description
IL-18Rα/IL-1R5 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD218a; CD218a; CDw218a; IL18R1; IL18RA; IL 18Ralpha; IL 18R alpha; IL18Ralpha2; IL1RRP; IL 1Rrp; Interleukin 18 receptor 1; IL 1 R5; IL 1 Rrp; IL 18 R alpha; IL 18 R1; IL18R alpha; IL18R1; IL 18Ra Accession Q13478 Amino Acid Sequence Cys22 Arg329, with C hIgG Fc Expression System HEK293 Molecular Weight 80 90kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical
Product Specification
| Species | Human |
| Synonyms | CD218a;CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra |
| Accession | Q13478 |
| Amino Acid Sequence | Cys22-Arg329, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 80-90kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967. |
Background
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either. independently of SLC12A3, or as a complex with SLC12A3.
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