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Description
WTAP Recombinant Rabbit mAb (S-2741-49)Product Specification Host Rabbit Antigen WTAP Synonyms Pre mRNA splicing regulator WTAP; Female lethal(2)D homolog (hFL(2)D); WT1 associated protein; Wilms tumor 1 associating protein; KIAA0105 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q15007 Clone Number S 2741 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample Molt 4, K562, Jurkat, HeLa, HepG2, RAW264. 7, mouse
Product Specification
| Host | Rabbit |
| Antigen | WTAP |
| Synonyms | Pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog (hFL(2)D); WT1-associated protein; Wilms tumor 1-associating protein; KIAA0105 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q15007 |
| Clone Number | S-2741-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Molt-4, K562, Jurkat, HeLa, HepG2, RAW264.7, mouse spleen, C6, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Rt |
Background
WTAP (Wilms tumor 1-associating protein) is a 44 kDa nuclear regulatory subunit of the m⁶A methyltransferase complex that, although catalytically inactive itself, orchestrates N6-methyladenosine modification of mRNA by docking the catalytic METTL3–METTL14 heterodimer onto nuclear speckles, thereby dictating transcript-specific methylation patterns that influence splicing, stability, translation, and cell-cycle progression, and its dysregulation is implicated in developmental defects, male sterility, and tumorigenesis where it can act as either oncogene or tumor suppressor depending on cellular context.
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