SKU: 99798902218

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 99798902218

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4.0 ★★★★★
Based on 24 reviews
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Cmarr
Los Angeles, US
★★★★★ 5
QDAN has great durable dog toys
Size: 8 Inch, Color: Yellow
It’s very durable ball lots of fun for dogs
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 24, 2026
B
Verified Purchase
Brown
Omaha, US
★★★★★ 5
So much fun
Size: 8 Inch, Color: Pink
Best money ever spent hours of fun. We have 3 dogs. They all love to play with this toy. We got the size 3 large is what we ordered. I'm not going to lie I thought it would be bigger when I ordered it. Two of our dogs are large breeds and the other is medium. It's not too big for the medium to play with it. It comes with a ball pump included so convenient. The little tabs are very durable. I can't recommend this enough. This has no squeaking or any sounds. It's nice that you can play with your four legged companion or you can have them play tug or just enjoy pushing the ball around. It is very versatile in play and stimulation.
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Reviewed in the United States on June 8, 2025
A
Verified Purchase
allyson handabaka
Fort Morgan, US
★★★★★ 3
Not for chewers
Size: 8 Inch, Color: Yellow, Size: 8 Inch, Color: Yellow
My dog managed to pop this and completely chew through it in a matter of 4 days. It was definitely cute and she loved the size of it but with her chewing all the way to the core we have to get rid of it. I thought it was a good material but I guess I was wrong. Kind of sad considering the money spent only lasted 4 days
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Reviewed in the United States on April 9, 2026
J
Verified Purchase
Jessica
Massapequa, US
★★★★★ 5
Great dog toy
Size: 8 Inch, Color: Pink
The amount of stupid and cute these dogs look like when they shake this ball and smack their own faces! It took a hot second for either dog to understand where to bite on the ball, but now that they do, they both will play with it for a while. Great purchase, came with a pump to blow the ball up.
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Reviewed in the United States on January 14, 2026
B
Verified Purchase
Beach Lover (Sue)
Natrona Heights, US
★★★★★ 5
Pup loves this!
Size: 6 Inch, Color: Red
This soccer ball is so cute. My dog loves to play with these. The straps are durable, easy to pump up (they come with a pump), good value for the money since they tend to last awhile, at least for us. The straps are durable but could be an issue if your dog is an aggressive chewer. They stay pumped up for quite awhile and just need to be topped off once in awhile to keep the bounce there. We keep them outside even in the winter and they do just fine. HIghly recommend as a good play toy.
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Reviewed in the United States on December 16, 2025

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