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Description
Pacific Blue Mouse Anti-Human CD134 Antibody (S-R589)Product Specification Host Mouse Antigen CD134 Synonyms Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; TXGP1L; TNFRSF4 Location Membrane Accession P43489 Clone Number S R589 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample PHA treated human peripheral blood mononuclear cells Purification Protein G Concentration 0. 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD134 |
| Synonyms | Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; TNFRSF4 |
| Location | Membrane |
| Accession | P43489 |
| Clone Number | S-R589 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | PHA treated human peripheral blood mononuclear cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD134, also known as OX40 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor superfamily. It is primarily expressed on activated CD4+ and CD8+ T cells, as well as other immune cells like natural killer (NK) cells and dendritic cells. CD134 plays a crucial role in enhancing T-cell proliferation, cytokine production, and survival by interacting with its ligand, CD134L (OX40L), which is mainly expressed on antigen-presenting cells (APCs) such as dendritic cells and macrophages. This interaction promotes T-cell-mediated immune responses and helps maintain memory T cells, making CD134 an important target for immunotherapy. In cancer treatment, agonistic antibodies targeting CD134 have been shown to enhance anti-tumor immunity by boosting T-cell activity and overcoming immune suppression.
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